Biology:SPHK2
 Generic protein structure example |
Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.[1]
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].[1]
The researchers also found that the expression of sphingosine kinase 2 (SphK2) and the secretion of sphingosine-1-phosphate (S1P) were significantly upregulated in the lungs of CS-exposed mice with COPD-like symptoms.[2]
Inhibitors
- Opaganib
References
- ↑ 1.0 1.1 "Entrez Gene: Sphingosine kinase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=56848. Retrieved 2011-12-22.
- ↑ Chen, Yanhui; Zhang, Yongrong; Rao, Cheng; Huang, Jieyun; Qing, Qiong (2023-03-16). "Deletion of sphingosine kinase 2 attenuates cigarette smoke-mediated chronic obstructive pulmonary disease-like symptoms by reducing lung inflammation" (in en). Biomolecules and Biomedicine 23 (2): 259–270. doi:10.17305/bjbms.2022.8034. ISSN 2831-090X. PMID 36226596. PMC 10113950. https://www.bjbms.org/ojs/index.php/bjbms/article/view/8034.
Further reading
- "Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform". The Journal of Biological Chemistry 275 (26): 19513–20. June 2000. doi:10.1074/jbc.M002759200. PMID 10751414.
- "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling". The Journal of Biological Chemistry 277 (10): 7996–8003. March 2002. doi:10.1074/jbc.M111423200. PMID 11777919.
- "Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases". Molecular and Cellular Biology 22 (22): 7758–68. November 2002. doi:10.1128/mcb.22.22.7758-7768.2002. PMID 12391145.
- "The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2". FEBS Letters 554 (1–2): 189–93. November 2003. doi:10.1016/S0014-5793(03)01168-2. PMID 14596938.
- "Role of sphingosine kinase 2 in cell migration toward epidermal growth factor". The Journal of Biological Chemistry 280 (33): 29462–9. August 2005. doi:10.1074/jbc.M502922200. PMID 15951439.
- "Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis". The Journal of Biological Chemistry 280 (43): 36318–25. October 2005. doi:10.1074/jbc.M504507200. PMID 16103110.
- "IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses". The Journal of Biological Chemistry 281 (5): 2515–25. February 2006. doi:10.1074/jbc.M508931200. PMID 16316995.
- "FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1". Circulation Research 99 (5): 468–76. September 2006. doi:10.1161/01.RES.0000239410.65551.b3. PMID 16888242.
- "Sphingosine kinase type 2 activation by ERK-mediated phosphorylation". The Journal of Biological Chemistry 282 (16): 12058–65. April 2007. doi:10.1074/jbc.M609559200. PMID 17311928.
- "Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2". The Journal of Biological Chemistry 282 (37): 27493–502. September 2007. doi:10.1074/jbc.M701641200. PMID 17635916.
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