Biology:Sphingosine kinase 1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene.[1][2]
Sphingosine kinase 1 phosphorylates sphingosine to sphingosine-1-phosphate (S1P). SK1 is normally a cytosolic protein but is recruited to membranes rich in phosphatidate (PA), a product of phospholipase D (PLD).[3]
Sphingosine-1-phosphate (S1P) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1. Various stimuli increase cellular levels of S1P by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of S1P and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor and serum.[2]
Interactions
SPHK1 has been shown to interact with TRAF2.[4]
References
- ↑ "Molecular cloning and functional characterization of murine sphingosine kinase". The Journal of Biological Chemistry 273 (37): 23722–8. Sep 1998. doi:10.1074/jbc.273.37.23722. PMID 9726979.
- ↑ 2.0 2.1 "Entrez Gene: SPHK1 sphingosine kinase 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8877.
- ↑ "Sphingosine Kinase 1 Is an Intracellular Effector of Phosphatidic Acid". The Journal of Biological Chemistry 279 (43): 44763–44774. 2004. doi:10.1074/jbc.M405771200. PMID 15310762.
- ↑ "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling". The Journal of Biological Chemistry 277 (10): 7996–8003. Mar 2002. doi:10.1074/jbc.M111423200. PMID 11777919.
Further reading
- "[Molecular diversity of sphingosine kinase]". Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme 47 (4 Suppl): 509–13. Mar 2002. PMID 11915350.
- "2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library". Genomics 24 (2): 276–9. Nov 1994. doi:10.1006/geno.1994.1616. PMID 7698749.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Generation and analysis of 280,000 human expressed sequence tags". Genome Research 6 (9): 807–28. Sep 1996. doi:10.1101/gr.6.9.807. PMID 8889549.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform". The Journal of Biological Chemistry 275 (26): 19513–20. Jun 2000. doi:10.1074/jbc.M002759200. PMID 10751414.
- "Functional characterization of human sphingosine kinase-1". FEBS Letters 473 (1): 81–4. May 2000. doi:10.1016/S0014-5793(00)01510-6. PMID 10802064.
- "Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution". Gene 251 (1): 19–26. Jun 2000. doi:10.1016/S0378-1119(00)00205-5. PMID 10863092.
- "Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes". The Biochemical Journal 350 Pt 2 (2): 429–41. Sep 2000. doi:10.1042/0264-6021:3500429. PMID 10947957.
- "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling". The Journal of Biological Chemistry 277 (10): 7996–8003. Mar 2002. doi:10.1074/jbc.M111423200. PMID 11777919.
- "Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells". The Journal of Biological Chemistry 277 (19): 17255–62. May 2002. doi:10.1074/jbc.M110944200. PMID 11856736.
- "Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein". The Journal of Biological Chemistry 277 (36): 33319–24. Sep 2002. doi:10.1074/jbc.M201442200. PMID 12077123.
- "Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity". The Journal of Biological Chemistry 277 (36): 32947–53. Sep 2002. doi:10.1074/jbc.M202841200. PMID 12080051.
- "PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)". The Journal of Biological Chemistry 277 (38): 35257–62. Sep 2002. doi:10.1074/jbc.M203033200. PMID 12124383.
- "The nucleotide-binding site of human sphingosine kinase 1". The Journal of Biological Chemistry 277 (51): 49545–53. Dec 2002. doi:10.1074/jbc.M206687200. PMID 12393916.
- "Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells". Experimental Cell Research 281 (1): 115–27. Nov 2002. doi:10.1006/excr.2002.5658. PMID 12441135.
- "Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents". Journal of Immunology 169 (11): 6394–400. Dec 2002. doi:10.4049/jimmunol.169.11.6394. PMID 12444147.
External links
- "Sphingosine kinase 1". UCSD Nature Molecule Pages (Signaling Gateway: University of California San Diego (UCSD) and Nature Publishing Group). 2007-11-08. doi:10.1038/mp.a002219.01. http://www.signaling-gateway.org/molecule/query?afcsid=A002219. Retrieved 2008-09-15.
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