Biology:Sterol esterase
| sterol esterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.1.13 | ||||||||
| CAS number | 9026-00-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Sterol esterases (EC 3.1.1.13) (also called cholesterol esterases) are enzymes that act to remove fatty acids attached to cholesterol (or more general sterols). In particular, they catalyzes the reaction
- a sterol ester + H2O a sterol + a fatty acid
A common example of a sterol ester would be a cholesterol ester, which is essentially a cholesterol molecule with a fatty acid attached. This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. In humans, the main proteins known to perform this function are the pancreatic digestive enzyme carboxyl ester lipase, the lysosome enzyme Lipase A, the liver detoxification enzyme carboxylesterase 1, and the skin enzyme Lipase member N.[1] However, the activity of these enzymes is not limited to acting on sterol esters, and for example most can also act as true lipases (EC 3.1.1.3) and break down fats (triglycerides).[2]
The systematic name is steryl-ester acylhydrolase. Other names in common use include cholesterol esterase, cholesteryl ester synthase, triterpenol esterase, cholesteryl esterase, cholesteryl ester hydrolase, sterol ester hydrolase, cholesterol ester hydrolase, cholesterase, and acylcholesterol lipase. This enzyme participates in bile acid biosynthesis.
References
- ↑ "ENZYME entry: EC 3.1.1.13". SIB Swiss Institute of Bioinformatics. https://purl.expasy.org/enzyme/EC/3.1.1.13.
- ↑ "ENZYME entry: EC 3.1.1.3". SIB Swiss Institute of Bioinformatics. https://purl.expasy.org/enzyme/EC/3.1.1.3.
Further reading
- "Purification and properties of pancreatic juice cholesterol esterase". J. Biol. Chem. 244 (7): 1937–45. 1969. doi:10.1016/S0021-9258(18)91769-2. PMID 5780846.
- "Studies on sterol-ester hydrolase from Fusarium oxysporum. I Partial purification and properties". J. Biochem. (Tokyo) 81 (5): 1209–15. May 1977. PMID 19426.
- "Enzymatic synthesis and hydrolysis of cholesterol esters". Methods of Biochemical Analysis. 16. 1968. pp. 219–72. doi:10.1002/9780470110348.ch4. ISBN 978-0-470-11034-8. https://archive.org/details/trent_0116402913226/page/219.
- Warnaar F (1987). "Triterpene ester synthesis in latex of Euphorbia species". Phytochemistry 26 (10): 2715–2721. doi:10.1016/S0031-9422(00)83578-5. Bibcode: 1987PChem..26.2715W.
 |  |
