Biology:Tuberculosinol synthase
From HandWiki
| Tuberculosinol synthase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.1.7.8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Tuberculosinol synthase (EC 3.1.7.8, Rv3378c) is an enzyme with systematic name tuberculosinyl diphosphate diphosphohydrolase (tuberculosinol forming).[2][3] This enzyme catalyses the following chemical reaction
- tuberculosinyl diphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] [tuberculosinol] + diphosphate
This enzyme is present in Mycobacterium that cause tuberculosis.
References
- ↑ "Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c". Proceedings of the National Academy of Sciences of the United States of America 111 (8): 2978–83. February 2014. doi:10.1073/pnas.1315883111. PMID 24516143. Bibcode: 2014PNAS..111.2978L.
- ↑ "Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome". Bioscience, Biotechnology, and Biochemistry 75 (1): 75–81. 2011. doi:10.1271/bbb.100570. PMID 21228491.
- ↑ "Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis". Organic & Biomolecular Chemistry 9 (7): 2156–65. April 2011. doi:10.1039/c0ob00884b. PMID 21290071.
External links
- Tuberculosinol+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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