Chemistry:1SB-LSD

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1SB-LSD, or 1BS-LSD, also known as 1-TMSBz-LSD or as 1-(4-(trimethylsilyl)benzoyl)-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[1][2] It is thought to be a prodrug of LSD.[1] The drug was encountered online as a novel designer drug in September 2025.[1][2] 1SB-LSD has been sold in the form of blotter, for instance containing 165 μg per tab.[1][2] It is the derivative of 1Bz-LSD (SYN-L-018) in which there is a 4-trimethylsilyl group on the benzyl ring.[1][2][3] 1SB-LSD was first described in the scientific literature by 2026.[2] It is not an explicitly controlled substance in the United States[4] or in Canada.[5]

See also

  • Substituted lysergamide

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 "1BS-LSD" (in ru). https://aipsin.com/newsubstance/1823/. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 "Identification and Analysis of Lysergic Acid Diethylamide Analogs, 4-Benzoyl-N,N-Diethyl-7-Methyl-4,6,6a,7,8,9-Hexahydroindolo[4,3-fg]quinoline-9-Carboxamide (1Bz-LSD) and N,N-Diethyl-7-Methyl-4-(4-(Trimethylsilyl)Benzoyl)-4,6,6a,7,8,9-Hexahydroindolo[4,3-fg]quinoline-9-Carboxamide (1-TMSBz-LSD), in tablet or paper sheet products available online in Japan". Drug Test Anal 18 (4): 510–517. April 2026. doi:10.1002/dta.70039. PMID 41709646. 
  3. ↑ Stratford A, Williamson JP, "Prodrugs of Substituted Ergolines", WO patent 2024/028495, published 8 February 2024
  4. ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026, https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf 
  5. ↑ "Controlled Drugs and Substances Act". 5 December 2025. https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 



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