Chemistry:Cofetuzumab pelidotin
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| Monoclonal antibody | |
|---|---|
| Type | ? |
| Source | Humanized (from mouse) |
| Target | protein tyrosine kinase 7 |
| Clinical data | |
| Other names | PF-06647020 |
| ATC code |
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| Identifiers | |
| CAS Number | |
| ChemSpider |
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| UNII | |
| KEGG | |
| Chemical and physical data | |
| Formula | C6774H10418N1778O2096S46 |
| Molar mass | 151776.97 g·mol−1 |
Cofetuzumab pelidotin (INN;[1] development code PF-06647020) is an experimental antibody-drug conjugate in development for the treatment of cancer. It was created by Stemcentrx and is being developed by Pfizer.[2] The drug is an anti-PTK7 monoclonal antibody linked to auristatin-0101, an auristatin microtubule inhibitor.[3][4]
Antibody-drug conjugates use a monoclonal antibody that binds to tumors cells linked to a cytotoxic drug that then kills the cells. This allows the drug to selectively target the cells that the antibody binds to.[citation needed]
PTK7 is expressed by many tumors, including ovarian cancer, breast cancer, and non-small cell lung cancer.[5] Early clinical trial results show a 50% response rate in patients with triple negative breast cancer and an almost complete response in ovarian tumors resistant to platinum-based chemotherapies.[6]
References
- ↑ World Health Organization (2017). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 117". WHO Drug Information 31 (2). https://www.who.int/medicines/publications/druginformation/innlists/PL115.pdf.
- ↑ Statement On A Nonproprietary Name Adopted By The USAN Council - Cofetuzumab Pelidotin, American Medical Association.
- ↑ "PF-06647020 Archives – ADC Review ADC Review". Adcreview.com. http://adcreview.com/tag/pf-06647020/.
- ↑ "Pfizer Oncology: ADC Development Overview (2016) – ADC Review ADC Review". Adcreview.com. http://adcreview.com/pfizer-adc-development-overview-2016/.
- ↑ "Antibody-Drug Conjugates (ADCs)". Pfizer Oncology. http://www.pfizer.com/files/news/esmo/ESMO2016_Oncology_Technologies_Fact_Sheet_ADC.pdf.
- ↑ "Why AbbVie Expects PTK7 to Enhance Its Oncology Capabilities". Market Realist. 2016-06-28. http://marketrealist.com/2016/06/abbvie-expects-ptk7-targeted-drug-enhance-oncology-capabilities/.
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