Chemistry:Lorvotuzumab mertansine
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Short description: Chemical compound
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| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Humanized |
| Target | CD56 |
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Lorvotuzumab mertansine (IMGN901) is an antibody-drug conjugate. It comprises the CD56-binding antibody, lorvotuzumab (huN901), with a maytansinoid cell-killing agent, DM1, attached using a disulfide linker, SPP. (When DM1 is attached to an antibody with the SPP linker, it is mertansine; when it is attached with the thioether linker, SMCC, it is emtansine.) [citation needed]
Lorvotuzumab mertansine is an experimental agent created for the treatment of CD56 positive cancers (e.g. small-cell lung cancer, ovarian cancer).[1][2]
It has been granted Orphan drug status for Merkel cell carcinoma.[3]
It has reported encouraging Phase II results for small-cell lung cancer.[4]
References
- ↑ "Antibody-Drug Conjugates Stage a Comeback". Genetic Engineering & Biotechnology News. 9 March 2010. http://www.genengnews.com/analysis-and-insight/antibody-drug-conjugates-stage-a-comeback/77899350/.
- ↑ ImmunoGen reports encouraging clinical data of IMGN901. News-medical.net. Retrieved on 2010-11-20.
- ↑ "ImmunoGen receives FDA orphan drug designation for IMGN901 compound in treatment of MCC". News-Medical.net. 8 March 2010. http://www.news-medical.net/news/20100308/ImmunoGen-receives-FDA-orphan-drug-designation-for-IMGN901-compound-in-treatment-of-MCC.aspx.
- ↑ "ImmunoGen Announces Encouraging New Clinical Data With The Company's IMGN901 Compound In The Treatment Of Small-Cell Lung Cancer". 2009. http://lungcancer.nocancersite.com/html/2011/02/1745.html.[yes|permanent dead link|dead link}}]
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