Chemistry:Farletuzumab

From HandWiki
Short description: Chemical compound
Farletuzumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized
TargetFR-alpha
Clinical data
Routes of
administration
Intravenous injection
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6466H9928N1716O2020S42
Molar mass145371.06 g·mol−1
 ☒N☑Y (what is this?)  (verify)

Farletuzumab (MORAb-003) is a humanized monoclonal antibody[1] of IgG1/κ[2] which is being investigated for the treatment of ovarian cancer.[3][4]

This drug was developed by Morphotek, Inc.

It is targeted at folate receptor alpha (FRα) which is overexpressed in some cancers such as epithelial ovarian cancer (EOC) and non-small-cell lung carcinoma.[2]

Mechanism of action

Farletuzumab uses the following mechanisms of action:[2]

  • Antibody-dependent cellular cytotoxicity
  • Complement-dependent cytotoxicity
  • Inhibition of interaction between FRα and Lyn kinase
  • Induces cell death associated with autophagy

Adverse effects

Common adverse effects include hypersensitivity reactions, fever, chills, headache, fatigue, and diarrhea.[2]

References

  1. Statement On A Nonproprietary Name Adopted By The Usan Council - Farletuzumab, American Medical Association.
  2. 2.0 2.1 2.2 2.3 "Profile of farletuzumab and its potential in the treatment of solid tumors". OncoTargets and Therapy 9: 1181–8. 2016-03-07. doi:10.2147/OTT.S98242. PMID 27022278. 
  3. Clinical trial number NCT00738699 for "Phase II Efficacy and Safety Study of MORAb-003 in Platinum-Resistant or Refractory Relapsed Ovarian Cancer" at ClinicalTrials.gov
  4. Clinical trial number NCT00849667 for "Phase III Efficacy and Safety of MORAb-003 in Subjects With Platinum-sensitive Ovarian Cancer in First Relapse" at ClinicalTrials.gov