Chemistry:Technetium (99mTc) nofetumomab merpentan
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| Monoclonal antibody | |
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| Type | Fab fragment |
| Source | Mouse |
| Clinical data | |
| Trade names | Verluma |
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| Pharmacokinetic data | |
| Elimination half-life | 10.5 hours |
| Excretion | renal (64%) |
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Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis of lung cancer,[1] gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma.[2] The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc).[3]
Nofetumomab
Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM.[4] and/or CD20/MS4A1[5]
It is the Fab part of murine MAb NR-LU-10.[6]
Merpentan
The chelator part : merpentan is a phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.[6]
Phenthioate
Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate[7]
References
- ↑ "Tc-99m nofetumomab merpentan complements an equivocal bone scan for detecting skeletal metastatic disease from lung cancer". Clinical Nuclear Medicine 25 (1): 54–5. January 2000. doi:10.1097/00003072-200001000-00013. PMID 10634533.
- ↑ "Clinical experience with Tc-99m nofetumomab merpentan (Verluma) radioimmunoscintigraphy". Clinical Nuclear Medicine 22 (9): 615–20. September 1997. doi:10.1097/00003072-199709000-00007. PMID 9298295.
- ↑ "International Nonproprietary Names (INN) for pharmaceutical substances". Geneva: World Health Organization. 2002. http://apps.who.int/medicinedocs/pdf/s4894e/s4894e.pdf.
- ↑ "Humanization of monoclonal antibodies". Molecular Biology of B Cells. Academic Press. January 2004. pp. 533–545. ISBN 978-0-08-047950-7. https://books.google.com/books?id=fF8d3eZ6SZ8C&pg=PA533.
- ↑ "Anti-MS4A1 Therapeutic Antibody (Technetium (99MTC) Nofetumomab Merpentan)". Creative BioLabs. http://www.creativebiolabs.net/Anti-MS4A1-Therapeutic-Antibody-VERLUMA-13782.htm.
- ↑ 6.0 6.1 Mudd, Efrain (27 February 2015). "Monoclonal Antibody Radionuclide Test Kits". Pharmacological Sciences. http://www.pharmacologicalsciences.us/pharmaceutical-chemistry/monoclonal-antibody-radionuclide-test-kits.html.
- ↑ Drabek J, Varsanyi D, "Insecticidal composition and method utilizing phosphoric acid phenylsulphonamide esters", US patent 3934010, issued 20 January 1976, assigned to Ciba Geigy Corporation
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