Chemistry:3F8
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Short description: Monoclonal antibody
| Monoclonal antibody | |
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| Type | ? |
| Source | Mouse |
| Target | GD2 |
| Clinical data | |
| Routes of administration | intravenous |
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3F8 is a murine IgG3[1] monoclonal antibody which binds to GD2.[2]
It has been used in the detection and treatment of neuroblastoma.[3] For imaging neuroblastoma, it is labelled with one of the radioisotopes iodine-124 and iodine-131.[4][5]
See also
References
- ↑ "GM-CSF enhances 3F8 monoclonal antibody-dependent cellular cytotoxicity against human melanoma and neuroblastoma". Blood 73 (7): 1936–41. May 1989. doi:10.1182/blood.V73.7.1936.1936. PMID 2653466.
- ↑ "Sloan-Kettering - Neuroblastoma: 3F8 Monoclonal Antibody Therapy Q & A". http://www.mskcc.org/mskcc/html/3215.cfm#261335.
- ↑ "Advances in the diagnosis and treatment of neuroblastoma". The Oncologist 8 (3): 278–92. 1 June 2003. doi:10.1634/theoncologist.8-3-278. PMID 12773750.
- ↑ "Radioimmunodetection of neuroblastoma with iodine-131-3F8: correlation with biopsy, iodine-131-metaiodobenzylguanidine and standard diagnostic modalities". Journal of Nuclear Medicine 32 (5): 769–76. May 1991. PMID 1902508. http://jnm.snmjournals.org/cgi/pmidlookup?view=long&pmid=1902508.
- ↑ "Whole-body clearance kinetics and external dosimetry of 131I-3F8 monoclonal antibody for radioimmunotherapy of neuroblastoma". Health Physics 92 (1): 33–9. January 2007. doi:10.1097/01.HP.0000231583.32904.6c. PMID 17164597.
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