Chemistry:Fosdevirine
From HandWiki
Short description: Chemical compound
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| Other names | GSK2248761; GSK2248761A; IDX-12899; IDX-899 |
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| Formula | C20H17ClN3O3P |
| Molar mass | 413.80 g·mol−1 |
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Fosdevirine is an experimental antiviral agent of the non-nucleoside reverse transcriptase inhibitor class that was studied for potential use in the treatment of HIV-AIDS.[1][2]
It was discovered by Idenix Pharmaceuticals and was being developed by GlaxoSmithKline and ViiV Healthcare, but it has now been discontinued[3][4] due to unexpected side effects.[5]
References
- ↑ "Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor". Journal of Medicinal Chemistry 59 (5): 1891–8. March 2016. doi:10.1021/acs.jmedchem.5b01430. PMID 26804933.
- ↑ "Fosdevirine". AIDSinfo. U.S. National Library of Medicine, U.S. Department of Health and Human Services. https://aidsinfo.nih.gov/drugs/552/fosdevirine/0/professional.
- ↑ "Fosdevirine". Adis Insight. Springer Nature Switzerland AG. https://adisinsight.springer.com/drugs/800027243. "Highest Development Phases: Discontinued, HIV-1 infections"
- ↑ "Fosdevirine". MedKoo Biosciences. https://www.medkoo.com/products/7914. "GSK2248761 is no longer in clinical development."
- ↑ "Unexpected finding of delayed-onset seizures in HIV-positive, treatment-experienced subjects in the Phase IIb evaluation of fosdevirine (GSK2248761)". Antiviral Therapy 19 (1): 69–78. 2013. doi:10.3851/IMP2689. PMID 24158593.
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