Chemistry:LEK-8827

From HandWiki

LEK-8827, also known as 6-methyl-LEK-8842 or as 6-methyl-N-methyl-N-(2-propynyl)lysergamide, is a chemical compound of the lysergamide family.[1] It is the 6-methyl derivative of LEK-8842 and is a quaternary ammonium compound.[1] The drug shows almost complete elimination of affinity for serotonin 5-HT2 and α-adrenergic receptors compared to LEK-8842, with no affinity for serotonin 5-HT2 receptors and slight but negligible affinity for α-adrenergic receptors.[1] Its loss of activity was said to probably be due to the increased polarity of the molecule.[1] LEK-8827 was first described in the scientific literature by 1992.[1] It was developed by the Slovenian pharmaceutical company LEK Pharmaceuticals.[1]

See also

  • Substituted lysergamide
  • LEK-8842
  • Nor-LSD (6-nor-LSD)

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 "Structure-activity study of some newly synthesized ergoline derivatives on 5-HT2 receptors and alpha-adrenoceptors in rabbit isolated aorta". Pharmacology 45 (4): 195–208. 1992. doi:10.1159/000138998. PMID 1332086.