Chemistry:Leriglitazone
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Short description: Chemical compound
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| Other names | Hydroxypioglitazone |
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| Formula | C19H20N2O4S |
| Molar mass | 372.44 g·mol−1 |
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Leriglitazone is a PPAR-gamma agonist and metabolite of the glitazone pioglitazone. It is developed for adrenomyeloneuropathy, and other neurodegenerative diseases.[1][2][3][4]
References
- ↑ Musokhranova, Uliana; Grau, Cristina; Vergara, Cristina; Rodríguez-Pascau, Laura; Xiol, Clara; Castells, Alba A.; Alcántara, Soledad; Rodríguez-Pombo, Pilar et al. (26 October 2023). "Mitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome". Journal of Translational Medicine 21 (1): 756. doi:10.1186/s12967-023-04622-5. ISSN 1479-5876. PMID 37884937.
- ↑ Pizcueta, Pilar; Vergara, Cristina; Emanuele, Marco; Vilalta, Anna; Rodríguez-Pascau, Laura; Martinell, Marc (6 February 2023). "Development of PPARγ Agonists for the Treatment of Neuroinflammatory and Neurodegenerative Diseases: Leriglitazone as a Promising Candidate". International Journal of Molecular Sciences 24 (4): 3201. doi:10.3390/ijms24043201. ISSN 1422-0067. PMID 36834611.
- ↑ Rodríguez-Pascau, Laura; Vilalta, Anna; Cerrada, Marc; Traver, Estefania; Forss-Petter, Sonja; Weinhofer, Isabelle; Bauer, Jan; Kemp, Stephan et al. (2 June 2021). "The brain penetrant PPARγ agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy". Science Translational Medicine 13 (596). doi:10.1126/scitranslmed.abc0555. PMID 34078742. https://zenodo.org/record/6419212.
- ↑ Pandolfo, Massimo; Reetz, Kathrin; Darling, Alejandra; Rodriguez de Rivera, Francisco Javier; Henry, Pierre-Gilles; Joers, James; Lenglet, Christophe; Adanyeguh, Isaac et al. (December 2022). "Efficacy and Safety of Leriglitazone in Patients With Friedreich Ataxia: A Phase 2 Double-Blind, Randomized Controlled Trial (FRAMES)". Neurology Genetics 8 (6): e200034. doi:10.1212/NXG.0000000000200034. PMID 36524101.
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