Chemistry:List of designer drugs

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An assortment of several designer drugs.

Designer drugs are structural or functional analogues of controlled substances that are designed to mimic the pharmacological effects of the parent drug while avoiding detection or classification as illegal. Many of the older designer drugs (research chemicals) are structural analogues of psychoactive tryptamines or phenethylamines but there are many other chemically unrelated new psychoactive substances that can be considered part of the designer drug group.[1][2][3][4] Designer drugs can also include substances that are not psychoactive in effect, such as analogues of controlled anabolic steroids and other performance and image enhancing drugs (PIEDs), including nootropics, weight loss drugs and erectile dysfunction medications. The pharmaceutical activities of these compounds might not be predictable based strictly upon structural examination. Many of the substances have common effects while structurally different or different effects while structurally similar due to SAR paradox. As a result of no real official naming for some of these compounds, as well as regional naming, this can all lead to potentially hazardous mix ups for users.[5] The following list is not exhaustive.

Psychedelics

A psychedelic substance is a psychoactive drug whose primary action is to alter cognition and perception. Psychedelics tend to affect and explore the mind in ways that result in the experience being qualitatively different from those of ordinary consciousness. The psychedelic experience is often compared to non-ordinary forms of consciousness such as trance, meditation, yoga, religious ecstasy, dreaming and even near-death experiences.

Lysergamides

Lysergamides are amide derivatives of the alkaloid lysergic acid.


Tryptamines

Drugs containing the tryptamine moiety are typically substrates for the serotonin receptors, in keeping with their close structural resemblance to serotonin, a neurotransmitter.


Benzofurans

Phenethylamines

Drugs containing the phenethylamine moiety bear close structural resemblance to dopamine but substitution on the benzene ring gives rise to drugs with a much higher affinity for serotonin receptors.


2C-x

2C-x class of psychedelics are 2,5-dimethoxy-phenethylamine derivatives.


NBxx

NNxx

DOx

The DOx family of psychedelics are also known as "substituted amphetamines" as they contain the amphetamine backbone but are substituted on the benzene ring. This gives rise to serotonin agonists similar to the 2C-X class but more resistant to elimination in the body.


Dissociatives

Dissociatives are a class of hallucinogens which distort perceptions of sight and sound and produce feelings of detachment - dissociation - from the environment and self. This is done through reducing or blocking signals to the conscious mind from other parts of the brain. Although many kinds of drugs are capable of such action, dissociatives are unique in that they do so in such a way that they produce hallucinogenic effects, which may include sensory deprivation, dissociation, hallucinations, and dream-like states or trances. Some, which are nonselective in action and affect the dopamine and/or opioid systems, may be capable of inducing euphoria. Many dissociatives have general depressant effects and can produce sedation, respiratory depression, analgesia, anesthesia, and ataxia, as well as cognitive and memory impairment and amnesia.

Arylcyclohexylamines

Arylcyclohexylamines are the oldest and most widely used dissociatives. The class includes the well known anaesthetic, ketamine.


Diarylethylamines

Misc

Piperazines

Piperazine containing designer drugs have effects similar to MDMA (ecstasy). This class of drugs are mimics of serotonin that activate 5-HT receptor subtypes that release norepinephrine and dopamine.


Empathogens

Empathogens are a class of psychoactive drugs that produce distinctive emotional and social effects similar to those of MDMA. Users of empathogens say the drugs often produce feelings of empathy, love, and emotional closeness to others.

MDxx

Substituted methylenedioxyphenethylamines (MDxx) are a large chemical class of derivatives of the phenethylamines, which includes many psychoactive drugs that act as entactogens, psychedelics, and/or stimulants, as well as entheogens.


Benzofurans

Benzofurans are similar in structure to MD(M)A but differ in that the methylenedioxy groups have been modified, removing one of the two oxygens in the methylenedioxy ring to render a benzofuran ring.


Miscellaneous polycyclic phenethylamines

Indane and tetralin-type phenethylamines are vaguely related to their amphetamine analogues.


Only one non-tryptamine indole has been sold, 5-IT. It shows strong MAOI activity.

  • 5-IT, 5-API, PAL-571

Tryptamines

Drugs containing the tryptamine moiety are typically substrates for the serotonin receptors, in keeping with their close structural resemblance to serotonin, a neurotransmitter.


Amphetamines

Substituted amphetamines are a chemical class of stimulants, entactogens, hallucinogens, and other drugs. They feature a phenethylamine core with a methyl group attached to the alpha carbon resulting in amphetamine, along with additional substitutions.


Stimulants

Stimulants produce a variety of different kinds of effects by enhancing the activity of the central and peripheral nervous systems. Common effects, which vary depending on the substance and dosage in question, may include enhanced alertness, awareness, wakefulness, endurance, productivity, and motivation, increased arousal, locomotion, heart rate, and blood pressure, and the perception of a diminished requirement for food and sleep.

Amphetamines

Amphetamines are a chemical class of stimulants, entactogens, hallucinogens, and other drugs. They feature a phenethylamine core with a methyl group attached to the alpha carbon resulting in amphetamine, along with additional substitutions.


Cathinones

Cathinones include some stimulants and entactogens, which are derivatives of cathinone. They feature a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon, along with additional substitutions.


Pyrrolidines and Pyrrolidinophenones

Pyrrolidines are amphetamines with a pyrrolidine group. Pyrrolidinophenones (also called Pyrovalerones) are cathinones (βk-amphetamines) with a pyrrolidine group.


Thiophenes

Thiophenes are stimulant drugs which are analogues of amphetamine or cathinone where the phenyl ring has been replaced by thiophene.


Tropanes and Piperidines

Tropane alkaloids occur in plants of the families erythroxylaceae (including coca). Piperidine and its derivatives are ubiquitous building blocks in the synthesis of many pharmaceuticals and fine chemicals.


Oxazolidines

Oxazolidines are a five-membered ring compounds consisting of three carbons, a nitrogen, and an oxygen. The oxygen and NH are the 1 and 3 positions, respectively. In oxazolidine derivatives, there is always a carbon between the oxygen and the nitrogen.


Phenylmorpholines

Phenylmorpholines are a class of stimulants containing a phenethylamine skeleton in which the terminal amine is incorporated into a morpholine ring.


Misc

Sedatives

Sedatives are substances that induces sedation by reducing irritability or excitement. At higher doses they may result in slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes. Doses of sedatives such as benzodiazepines, when used as a hypnotic to induce sleep, tend to be higher than amounts used to relieve anxiety, whereas only low doses are needed to provide a peaceful effect. Sedatives can be misused to produce an overly-calming effect. In the event of an overdose or if combined with another sedative, many of these drugs can cause unconsciousness and even death.

Opioids

Opioids have pharmacologic actions resembling morphine and other components of opium.


N-(2C)-fentanyl

Main page: Chemistry:N-(2C)-fentanyl


Benzodiazepines

Thienodiazepines

GHB analogues

Methaqualone analogues

Misc

Synthetic cannabinoids

Agonists of the central cannabinoid receptor type 1 mimic the behavioral effects of cannabis.

Classical cannabinoids

Cyclohexeylphenol cannabinoids

Miscellaneous cannabinoids

Indazole based

Indazole containing cannabinoid receptor agonists include:


Indole based

Indole containing cannabinoid receptor agonists include:


Quinolinylindoles

Benzoylindoles

Adamantoylindoles

Naphthoylindoles

Phenylacetylindoles

Androgens

Androgenic anabolic steroids have approved medical uses as well as used illicitly as performance-enhancing drugs to build muscle mass and strength. Anabolic steroids that have been designed to evade detection in sport doping tests are known as "designer steroids".[98][99]

Testosterone based

DHT based

Estranes

SARMs

Selective androgen receptor modulators (SARMs) are a novel class of androgen receptor ligands. They are intended to maintain the desirable muscle building effects of anabolic steroids while reducing undesirable androgenic actions (e.g., increased risk of prostate cancer). SARMs that are more selective in their action could potentially be used for a broader range of clinical indications other than the relatively limited legitimate uses that anabolic steroids are currently approved for.[100]


Others

Peptides

GHRH analogues

GHRH analogues stimulate the release of growth hormone.


Growth hormone secretagogue receptor agonists

Agonists of the growth hormone secretagogue receptor stimulate the release of growth hormone through the ghrelin receptor.


Others

PDE5 inhibitors

PDE5 inhibitors are typically used to treat pulmonary hypertension and erectile dysfunction.[102]


Nootropics

Part of this section is transcluded from Nootropic. (edit | history)

{{#Section-h:Nootropic|Types}}

Examples


See also


References

  1. ↑ "EMCDDA–Europol 2013 Annual Report on the information exchange, risk assessment and control of new psychoactive substances (implementation of Council Decision 2005/387/JHA)". EMCDDA. July 2014. https://www.emcdda.europa.eu/publications/implementation-reports/2013. 
  2. ↑ "EMCDDA–Europol 2012 Annual Report on the implementation of Council Decision 2005/387/JHA (New drugs in Europe, 2012)". EMCDDA. May 2013. https://www.emcdda.europa.eu/publications/implementation-reports/2012. 
  3. ↑ "EMCDDA–Europol 2011 Annual Report on the (information exchange, risk assessment and control of new psychoactive substances) implementation of Council Decision 2005/387/JHA". EMCDDA. April 2012. https://www.emcdda.europa.eu/publications/implementation-reports/2011. 
  4. ↑ "EMCDDA–Europol 2010 Annual Report on the implementation of Council Decision 2005/387/JHA". EMCDDA. May 2011. https://www.emcdda.europa.eu/publications/implementation-reports/2010. 
  5. ↑ "Combined intoxication with methylone and 5-MeO-MIPT". Progress in Neuro-Psychopharmacology & Biological Psychiatry 31 (1): 288–291. January 2007. doi:10.1016/j.pnpbp.2006.06.012. PMID 16876302. 
  6. ↑ "Analytical profile, in vitro metabolism and behavioral properties of the lysergamide 1P-AL-LAD". Drug Testing and Analysis 14 (8): 1503–1518. August 2022. doi:10.1002/dta.3281. PMID 35524430. 
  7. ↑ "4-HO-DALT". Isomerdesign. https://isomerdesign.com/PiHKAL/explore.php?domain=tk&id=5530. 
  8. ↑ "5-MeO-NiPT". Isomerdesign. https://isomerdesign.com/PiHKAL/explore.php?domain=tk&id=5088. 
  9. ↑ "N-[2-(1H-Indol-3-yl)ethyl-N-methylcyclopropanamine"]. PubChem. U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/67231643. 
  10. ↑ Phenethylamine Von der Struktur zur Funktion. Nachtschatten Verlag AG. 2013. ISBN 978-3-03788-700-4. 
  11. ↑ "Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane". Journal of Medicinal Chemistry 47 (24): 6034–6041. November 2004. doi:10.1021/jm040082s. PMID 15537358. 
  12. ↑ Beta-hydroxyphenylalkylamines and their use for treating glaucoma, https://patents.google.com/patent/US20060106106A1/en 
  13. ↑ "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs". Drug Testing and Analysis 6 (7–8): 614–632. 2014. doi:10.1002/dta.1620. PMID 24678061. 
  14. ↑ "Difluoromethylenedioxybenzylpiperazine". PubChem. U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/66553702. 
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  16. ↑ 16.0 16.1 "A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N-OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products". Forensic Toxicology 33 (2): 244–259. 1 July 2015. doi:10.1007/s11419-015-0268-7. PMID 26257833. 
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  18. ↑ "2-Methylethcathinone". Cayman Chemical. https://www.caymanchem.com/product/11221. 
  19. ↑ "2,4-Dimethylethcathinone". PubChem. U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/82100531. 
  20. ↑ "2,4-Dimethylmethcathinone". PubChem. U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/82100563. 
  21. ↑ 21.0 21.1 21.2 21.3 21.4 21.5 "Three 25-NBOMe-type drugs, three other phenethylamine-type drugs (25I-NBMD, RH34, and escaline), eight cathinone derivatives, and a phencyclidine analog MMXE, newly identified in ingredients of drug products before they were sold on the drug market". Forensic Toxicology 34 (1): 108–114. January 2016. doi:10.1007/s11419-015-0293-6. ISSN 1860-8965. 
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  23. ↑ "3-MeOMC". Cayman Chemical. https://www.caymanchem.com/product/9001187. 
  24. ↑ "3-MEC". SWGDRUG. 2013. https://www.swgdrug.org/Monographs/3-MEC.pdf. 
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  28. ↑ "4-FPD". Cayman Chemical. https://www.caymanchem.com/product/9002182. 
  29. ↑ 29.0 29.1 29.2 29.3 29.4 "Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, α-PHPP and α-POP, with 11 newly distributed designer drugs in illegal products". Forensic Science International 243: 1–13. October 2014. doi:10.1016/j.forsciint.2014.03.013. PMID 24769262. 
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  41. ↑ "4-MeO-PV-9". Cayman Chemical. https://www.caymanchem.com/product/15064. 
  42. ↑ "PV-10". Cayman Chemical. https://www.caymanchem.com/product/17138. 
  43. ↑ "5-Methyl-2-phenylmorpholine". PubChem. U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/12945120. 
  44. ↑ "3-Fluorophenetrazine Hydrochloride". https://www.trc-canada.com/product-detail/?F595070. 
  45. ↑ "4-Ethyl-3-methyl-2-phenylmorpholine". PubChem. U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/14425810. 
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  56. ↑ "Explore N-(2C-C)-Fentanyl | PiHKAL · info". https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14010. 
  57. ↑ "Explore N-(2C-D)-Fentanyl | PiHKAL · info". https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14008. 
  58. ↑ "Explore N-(2C-E)-Fentanyl | PiHKAL · info". https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14013. 
  59. ↑ "Explore N-(2C-G)-Fentanyl | PiHKAL · info". https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14011. 
  60. ↑ "Explore N-(2C-H)-Fentanyl | PiHKAL · info". https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=9531. 
  61. ↑ "Explore N-(2C-I)-Fentanyl | PiHKAL · info". https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14009. 
  62. ↑ "Explore N-(2C-IP)-Fentanyl | PiHKAL · info". https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14022. 
  63. ↑ "Explore N-(2C-N)-Fentanyl | PiHKAL · info". https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=13234. 
  64. ↑ "Explore N-(2C-P) fentanyl | PiHKAL · info". https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14023. 
  65. ↑ "Explore N-(2C-T)-Fentanyl | PiHKAL · info". https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14019. 
  66. ↑ "Explore N-(2C-T-2)-Fentanyl | PiHKAL · info". https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14025. 
  67. ↑ "Explore N-(2C-T-4)-Fentanyl | PiHKAL · info". https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14027. 
  68. ↑ "Explore N-(2C-T-7)-Fentanyl | PiHKAL · info". https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14026. 
  69. ↑ "Explore N-(2C-TFM)-Fentanyl | PiHKAL · info". https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=14028. 
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  77. ↑ "4F-MDMB-BINACA: A New Synthetic Cannabinoid Widely Implicated in Forensic Casework". Journal of Forensic Sciences 64 (5): 1451–1461. September 2019. doi:10.1111/1556-4029.14101. PMID 31260580. 
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  80. ↑ "5F-MN-18". Forendex. Southern Association of Forensic Scientists. http://forendex.safs1966.org/index.php/detail/index/1269. 
  81. ↑ "5F-NPB-22". Cayman Chemical. https://www.caymanchem.com/product/15536. 
  82. ↑ "5F-SDB-005". Forendex. Southern Association of Forensic Scientists. http://forendex.safs1966.org/index.php/detail/index/1273. 
  83. ↑ "AMB". Forendex. Southern Association of Forensic Scientists. http://forendex.safs1966.org/index.php/detail/index/1267. 
  84. ↑ "Detection and characterization of the new synthetic cannabinoid APP-BINACA in forensic casework". Drug Testing and Analysis 12 (1): 136–144. January 2020. doi:10.1002/dta.2698. PMID 31788963. 
  85. ↑ "Identification of N,N-bis(1-pentylindol-3-yl-carboxy)naphthylamine (BiPICANA) found in an herbal blend product in the Tokyo metropolitan area and its cannabimimetic effects evaluated by in vitro [35S]GTPγS binding assays". Forensic Toxicology 33: 84–92. November 2014. doi:10.1007/s11419-014-0253-6. 
  86. ↑ "Structure elucidation of the novel synthetic cannabinoid Cumyl-Tosyl-Indazole-3-Carboxamide (Cumyl-TsINACA) found in illicit products in Germany". Drug Testing and Analysis 14 (8): 1387–1406. August 2022. doi:10.1002/dta.3261. PMID 35338591. 
  87. ↑ Pulver, Benedikt; Fischmann, Svenja; Gallegos, Ana; Christie, Rachel (March 2023). "EMCDDA framework and practical guidance for naming synthetic cannabinoids". Drug Testing and Analysis 15 (3): 255–276. doi:10.1002/dta.3403. 
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  89. ↑ "FUB-NPB-22". Cayman Chemical. https://www.caymanchem.com/product/16883. 
  90. ↑ "NPB-22". Cayman Chemical. https://www.caymanchem.com/product/15535. 
  91. ↑ "Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA". ACS Chemical Neuroscience 6 (9): 1546–1559. September 2015. doi:10.1021/acschemneuro.5b00112. PMID 26134475. 
  92. ↑ "[1-(5-Fluoropentyl)indol-3-yl-pyrrolidin-1-ylmethanone"]. PubChem. U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/129520948. 
  93. ↑ "Four types of cannabimimetic indazole and indole derivatives, ADB-BINACA, AB-FUBICA, ADB-FUBICA, and AB-BICA, identified as new psychoactive substances". Forensic Toxicology 34 (1): 133–143. January 2016. doi:10.1007/s11419-015-0297-2. PMID 26793280. 
  94. ↑ "A new cannabinoid receptor 1 selective agonist evading the 2021 "China ban": ADB-FUBIATA". Drug Testing and Analysis 14 (9): 1639–1644. September 2022. doi:10.1002/dta.3285. PMID 35570246. 
  95. ↑ "Identification of the synthetic cannabinoid-type new psychoactive substance, CH-PIACA, in seized material". Drug Testing and Analysis 14 (9): 1645–1651. September 2022. doi:10.1002/dta.3333. PMID 35687099. 
  96. ↑ "CBL-018". Cayman Chemical. https://www.caymanchem.com/product/16443. 
  97. ↑ "Cross-substitution of Δ9-tetrahydrocannabinol and JWH-018 in drug discrimination in rats". Pharmacology, Biochemistry, and Behavior 124: 123–128. September 2014. doi:10.1016/j.pbb.2014.05.016. PMID 24887450. 
  98. ↑ "Designer Steroids". Doping in Sports. Handbook of Experimental Pharmacology. 195. 2009. pp. 155–85. doi:10.1007/978-3-540-79088-4_7. ISBN 978-3-540-79087-7. 
  99. ↑ "Advances in the detection of designer steroids in anti-doping". Bioanalysis 6 (6): 881–896. March 2014. doi:10.4155/bio.14.9. PMID 24702116. 
  100. ↑ "Deciphering the selective androgen receptor modulators paradigm". Expert Opinion on Drug Discovery 8 (2): 191–218. February 2013. doi:10.1517/17460441.2013.741582. PMID 23231475. 
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  102. ↑ Dhaliwal, Armaan; Gupta, Mohit (2023), "PDE5 Inhibitors", StatPearls (Treasure Island (FL): StatPearls Publishing), PMID 31751033, http://www.ncbi.nlm.nih.gov/books/NBK549843/, retrieved 2023-10-24 
  103. ↑ "Public Notification: "RigiRx Plus" Contains Undeclared Drug Ingredient". US FDA. 20 April 2012. https://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/MedicationHealthFraud/ucm301182.htm. 



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