Chemistry:Lumicitabine
From HandWiki
Short description: Chemical compound
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| Trade names | Lumicitabine |
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| Formula | C18H25ClFN3O6 |
| Molar mass | 433.9 g·mol−1 |
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Lumicitabine (ALS-8176) is an antiviral drug which was developed as a treatment for respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). It acts as an RNA polymerase inhibitor.[1] While it showed promise in early clinical trials,[2][3] poor results in Phase IIb trials led to it being discontinued from development for treatment of RSV.[4] Research continues to determine whether it may be useful for the treatment of diseases caused by other RNA viruses, and it has been found to show activity against Nipah virus.[5]
See also
- Palivizumab
- Presatovir
- Ziresovir
References
- ↑ "Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection". Journal of Medicinal Chemistry 58 (4): 1862–78. February 2015. doi:10.1021/jm5017279. PMID 25667954.
- ↑ "Antiviral treatment of severe non-influenza respiratory virus infection". Current Opinion in Infectious Diseases 30 (6): 573–578. December 2017. doi:10.1097/QCO.0000000000000410. PMID 29095723. https://eprints.soton.ac.uk/415733/1/COID_Manuscript_NJB.TWC.31.08.17._Final.docx.
- ↑ "Respiratory syncytial virus-A dynamics and the effects of lumicitabine, a nucleoside viral replication inhibitor, in experimentally infected humans". The Journal of Antimicrobial Chemotherapy 74 (2): 442–452. February 2019. doi:10.1093/jac/dky415. PMID 30376079.
- ↑ "Johnson & Johnson takes $630M hit on RSV drug bought with Alios.". fiercebiotech.com. 18 October 2018. https://www.fiercebiotech.com/biotech/j-j-takes-630m-hit-rsv-drug-bought-alios.
- ↑ "Potent in vitro activity of β-D-4'-chloromethyl-2'-deoxy-2'-fluorocytidine against Nipah virus". Antiviral Research 175: 104712. January 2020. doi:10.1016/j.antiviral.2020.104712. PMID 31935422.
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