Chemistry:Pildralazine
From HandWiki
Short description: Chemical compound
 | |
| Clinical data | |
|---|---|
| Other names | ISF-2123 |
| Routes of administration | Oral |
| ATC code |
|
| Legal status | |
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| Chemical and physical data | |
| Formula | C8H15N5O |
| Molar mass | 197.242 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Pildralazine (Atensil), also known as propyldazine or propildazine, is an antihypertensive and vasodilator.[1]
Synthesis
The reaction between 3,6-Dichloropyridazine [141-30-0] (1) and 1-(Methylamino)-2-propanol [16667-45-1] (2) gives CID:12237595 (3). Reaction with hydrazine completes the synthesis of Pidralazine (4).
References
- ↑ Dictionary of pharmacological agents. CRC Press. 1997. pp. 1603. ISBN 978-0-412-46630-4. https://books.google.com/books?id=A0THacd46ZsC&pg=PA1603. Retrieved 25 November 2011.
- ↑ "Synthesis and antihypertensive properties of new 3-hydrazinopyridazine derivatives.". Journal of Medicinal Chemistry 18 (7): 741–746. July 1975. doi:10.1021/jm00241a020. PMID 1151996.
- ↑ DE2154245 idem G Pifferi, U.S. Patent 3,769,278 (1973 to Isf Spa).
 |  |
