Chemistry:Phenylethylidenehydrazine
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Short description: Metabolite of an antidepressant drug
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| Elimination half-life | ~12 hours |
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| Formula | C8H10N2 |
| Molar mass | 134.182 g·mol−1 |
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Phenylethylidenehydrazine (PEH), also known as 2-phenylethylhydrazone or β-phenylethylidenehydrazine, is a GABA transaminase inhibitor.[1][2] It is a metabolite of the antidepressant phenelzine and is responsible for its elevation of GABA concentrations.[1] PEH may contribute to phenelzine's anxiolytic effects.[3]
See also
References
- ↑ 1.0 1.1 "Effects of the antidepressant/antipanic drug phenelzine and its putative metabolite phenylethylidenehydrazine on extracellular gamma-aminobutyric acid levels in the striatum". Biochemical Pharmacology 63 (1): 57–64. January 2002. doi:10.1016/S0006-2952(01)00856-5. PMID 11754874.
- ↑ "Phenylethylidenehydrazine, a novel GABA-transaminase inhibitor, reduces epileptiform activity in rat hippocampal slices". Neuroscience 126 (2): 423–432. 2004. doi:10.1016/j.neuroscience.2004.03.007. PMID 15207360.
- ↑ "Effects of the antidepressant phenelzine on brain levels of gamma-aminobutyric acid (GABA)". Journal of Affective Disorders 21 (3): 207–211. March 1991. doi:10.1016/0165-0327(91)90041-p. ISSN 0165-0327. PMID 1648582.
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