Chemistry:Phenoxypropazine
From HandWiki
Short description: Chemical compound
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| Routes of administration | Oral |
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| Formula | C9H14N2O |
| Molar mass | 166.224 g·mol−1 |
Phenoxypropazine (trade name Drazine) is an irreversible and non-selective monoamine oxidase inhibitor (MAOI) of the hydrazine family. It was introduced as an antidepressant in 1961, but was subsequently withdrawn in 1966 due to hepatotoxicity concerns.[1][2][3][4][5]
See also
References
- ↑ "A preliminary study of phenoxypropazine in the treatment of depression". The American Journal of Psychiatry 119 (10): 986–7. April 1963. doi:10.1176/ajp.119.10.986. PMID 13928824. http://ajp.psychiatryonline.org/cgi/pmidlookup?view=long&pmid=13928824.
- ↑ IMLAH NW (May 1963). "Preliminary report on phenoxypropazine". The American Journal of Psychiatry 119 (11): 1091–2. doi:10.1176/ajp.119.11.1091. PMID 13956423. http://ajp.psychiatryonline.org/cgi/pmidlookup?view=long&pmid=13956423.
- ↑ "A comparison of phenoxypropazine and amitriptyline in depression". The American Journal of Psychiatry 120 (4): 393–5. October 1963. doi:10.1176/ajp.120.4.393. PMID 14069469. http://ajp.psychiatryonline.org/cgi/pmidlookup?view=long&pmid=14069469.
- ↑ ROSE JT (March 1964). "Phenoxypropazine and chlordiazepoxide in depression". The American Journal of Psychiatry 120 (9): 899–900. doi:10.1176/ajp.120.9.899. PMID 14129290. http://ajp.psychiatryonline.org/cgi/pmidlookup?view=long&pmid=14129290.
- ↑ "Treatment of mild endogenous depression with a monoamine oxidase inhibitor: a controlled trial in general practice". The Journal of the College of General Practitioners 9 (1): 95–9. January 1965. PMID 14254271.
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