Chemistry:Pheniprazine
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Short description: Chemical compound
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| Routes of administration | Oral |
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| Formula | C9H14N2 |
| Molar mass | 150.225 g·mol−1 |
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Pheniprazine (INN; also known as amphethydrazine and amphetamine hydrazide; brand names Catron and Cavodil; codename JB-516) is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant in the 1960s.[1][2][3] It was also used in the treatment of angina pectoris and schizophrenia.[4][5] Pheniprazine has been largely discontinued due to toxicity concerns such as jaundice, amblyopia, and optic neuritis.[6][7][8]
See also
References
- ↑ "A controlled trial of cavodil (pheniprazine) in depression". The Journal of Mental Science 108 (457): 856–58. November 1962. doi:10.1192/bjp.108.457.856. PMID 13928843.
- ↑ "Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors". Biochemical Pharmacology 35 (8): 1381–7. April 1986. doi:10.1016/0006-2952(86)90285-6. PMID 2870717.
- ↑ "Studies on Monoamine Oxidase Inhibitors. I. The Autoxidation of β-Phenylisopropylhydrazine as a Model Reaction for Irreversible Monoamine Oxidase Inhibition". Journal of Medicinal and Pharmaceutical Chemistry 91 (4): 738–52. July 1962. doi:10.1021/jm01239a006. PMID 14056405.
- ↑ "Clinical evaluation of pheniprazine in angina pectoris". British Medical Journal 1 (5228): 792–4. March 1961. doi:10.1136/bmj.1.5228.792. PMID 13746179.
- ↑ "[beta-Phenylisoprophlhydrazine (Catran) in schizophrenia]". Nordisk Medicin 68: 1165–7. September 1962. PMID 14000469.
- ↑ "Fatal jaundice after administration of pheniprazine". British Medical Journal 2 (5267): 1616–7. December 1961. doi:10.1136/bmj.2.5267.1616. PMID 13892290.
- ↑ "Toxic amblyopia during antidepressant treatment with pheniprazine (Catran)". Acta Psychiatrica Scandinavica 38 (1): 1–14. 1962. doi:10.1111/j.1600-0447.1962.tb01780.x. PMID 13894598.
- ↑ "[Optic neuritis after treatment with Catran]". Ugeskrift for Laeger 125: 138–9. January 1963. PMID 13981222.
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