Chemistry:Mebanazine
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Short description: Chemical compound
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| Routes of administration | Oral |
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| Formula | C8H12N2 |
| Molar mass | 136.198 g·mol−1 |
Mebanazine (trade name Actomol) is a monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was previously used as an antidepressant in the 1960s, but has since been withdrawn due to hepatotoxicity.[1][2][3]
Mebanazine in animals is claimed to be a more potent MAOI than pheniprazine with a greater therapeutic index.[4]
See also
References
- ↑ Gilmour SJ (September 1965). "Clinical trial of mebanazine--a new monoamine oxidase inhibitor". The British Journal of Psychiatry 111 (478): 899–902. doi:10.1192/bjp.111.478.899. PMID 5889715.
- ↑ "A controlled trial of mebanazine ('Actomol') in depression". The British Journal of Psychiatry 111 (480): 1095–100. November 1965. doi:10.1192/bjp.111.480.1095. PMID 5320546.
- ↑ Knott F (1965). "A preliminary trial of mebanazine in depressive states". The Journal of New Drugs 5 (6): 345–7. doi:10.1002/j.1552-4604.1965.tb00259.x. PMID 5327282. http://jcp.sagepub.com/cgi/pmidlookup?view=long&pmid=5327282.[yes|permanent dead link|dead link}}]
- ↑ "Annual Reports in Medicinal Chemistry". Chapter 2. Antidepressants, Stimulants, Hallucinogens. Annual Reports in Medicinal Chemistry. 2. Elsevier. 1967. pp. 11–23. doi:10.1016/S0065-7743(08)61499-2. ISBN 9780120405022. https://linkinghub.elsevier.com/retrieve/pii/S0065774308614992.
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