Chemistry:Pirlimycin
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Pirlimycin, sold under the brand name Pirsue, is used in the treatment of mastitis in cattle.[1][2][3] It is used as the salt pirlimycin hydrochloride and it belongs to the lincosamide class of antimicrobials.[1]
Activity
Pirlimycin is active against Gram-positive bacteria, specifically Staphylococcus aureus and coagulase negative species of Staphylococcus and Streptococcus. It has no activity against Gram-negative bacteria.[4]
Mechanism of action
It is bacteriostatic and acts by inhibiting bacterial protein synthesis via binding with the 50S subunit of the ribosome.[citation needed]
References
- ↑ 1.0 1.1 Cite error: Invalid
<ref>tag; no text was provided for refs namedPirsue EPAR - ↑ "Activity of pirlimycin against pathogens from cows with mastitis and recommendations for disk diffusion tests". Antimicrobial Agents and Chemotherapy 37 (5): 1122–6. May 1993. doi:10.1128/AAC.37.5.1122. PMID 8517701.
- ↑ Mastitis in dairy production: current knowledge and future solutions. Wageningen: Wageningen Academic Publishers. 2005. p. 55. ISBN 978-90-76998-70-1. https://books.google.com/books?id=9hOA_wWF9iEC&dq=Pirlimycin&pg=PA55.
- ↑ "USP: Pirlimycin". http://www.usp.org/pdf/EN/veterinary/pirlimycin.pdf.
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