Biology:EPHA8

Generic protein structure example

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.

Function

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.

Interactions

EPHA8 has been shown to interact with FYN.

Further reading

• "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. 1998. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499. 
• "Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta.". Curr. Opin. Neurobiol. 8 (1): 117–27. 1998. doi:10.1016/S0959-4388(98)80015-9. PMID 9568399. 
• "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. 1998. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626. 
• "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. 1999. PMID 10207129. 
• Eph receptors and ephrins: regulators of guidance and assembly.. International Review of Cytology. 196. 2000. 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 9780123646002. 
• "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. 2001. doi:10.1098/rstb.2000.0635. PMID 11128993. 
• "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. 2001. doi:10.1038/35058515. PMID 11256076. 
• "Neurobiology: New connections between integrins and axon guidance.". Curr. Biol. 14 (3): R121–3. 2004. doi:10.1016/j.cub.2004.01.020. PMID 14986683. 
• "Eph receptors in the adult brain.". Curr. Opin. Neurobiol. 14 (3): 288–96. 2004. doi:10.1016/j.conb.2004.04.003. PMID 15194108. 
• "Eph receptors, ephrins, and synaptic function.". The Neuroscientist : A Review Journal Bringing Neurobiology, Neurology and Psychiatry 10 (4): 304–14. 2004. doi:10.1177/1073858403262221. PMID 15271258. 
• "The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands.". Oncogene 14 (5): 533–42. 1997. doi:10.1038/sj.onc.1200857. PMID 9053851. 
• "Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors.". EMBO J. 16 (11): 3106–14. 1997. doi:10.1093/emboj/16.11.3106. PMID 9214628. 
• "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.". Cell 90 (3): 403–4. 1997. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. 
• "A coherent nomenclature for Eph receptors and their ligands.". Mol. Cell. Neurosci. 9 (5–6): 331–2. 1998. doi:10.1006/mcne.1997.0630. PMID 9361271. 
• "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.". Oncogene 18 (39): 5413–22. 1999. doi:10.1038/sj.onc.1202917. PMID 10498895.