Biology:EPHB6

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.

Further reading

• "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. 1998. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499. 
• Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626. 
• "Eph receptors and ephrins: effectors of morphogenesis". Development 126 (10): 2033–44. 1999. doi:10.1242/dev.126.10.2033. PMID 10207129. 
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly; Chapter: Eph receptors and ephrins: Regulators of guidance and assembly". Int. Rev. Cytol.. International Review of Cytology 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 978-0-12-364600-2. PMID 10730216. 
• "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. 2001. doi:10.1098/rstb.2000.0635. PMID 11128993. 
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076. 
• "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "Expression of a kinase-defective Eph-like receptor in the normal human brain". Biochem. Biophys. Res. Commun. 235 (3): 487–92. 1997. doi:10.1006/bbrc.1997.6812. PMID 9207182. 
• Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. 
• "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. 1998. doi:10.1073/pnas.95.17.9779. PMID 9707552. Bibcode: 1998PNAS...95.9779H. 
• "Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6". FEBS Lett. 466 (1): 169–74. 2000. doi:10.1016/S0014-5793(99)01793-7. PMID 10648835. 
• "T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells". Growth Factors 18 (1): 63–78. 2000. doi:10.3109/08977190009003234. PMID 10831073. 
• "Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10936–41. 2000. doi:10.1073/pnas.190123297. PMID 10984508. Bibcode: 2000PNAS...9710936T. 
• "Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells". J. Immunol. 167 (3): 1362–70. 2001. doi:10.4049/jimmunol.167.3.1362. PMID 11466354.