Chemistry:Ficlatuzumab
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Short description: Monoclonal antibody
| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | HGF |
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| Chemical and physical data | |
| Formula | C6446H9954N1718O2026S46 |
| Molar mass | 145409.30 g·mol−1 |
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Ficlatuzumab is a humanized monoclonal antibody designed for the treatment of cancers.[1]
It is a humanized monoclonal antibody that binds to hepatocyte growth factor, thus inhibiting the c-MET receptor signaling cascade.[2]
Ficlatuzumab was developed by AVEO Pharmaceuticals. In May 2012, AVEO released results of a Phase II clinical trial comparing gefitinib alone and in combination with ficlatuzamab in treatment-naive Asian patients with non-small cell lung cancer.[3]
References
- ↑ "Statement On A Nonproprietary Name Adopted By The USAN Council: Ficlatuzumab". American Medical Association. http://www.ama-assn.org/resources/doc/usan/ficlatuzumab.pdf.
- ↑ "A Review of Monoclonal Antibody-Based Treatments in Non-small Cell Lung Cancer". Reviews on New Drug Targets in Age-Related Disorders. Advances in Experimental Medicine and Biology. 1286. 2021. pp. 49–64 (57). doi:10.1007/978-3-030-55035-6_3. ISBN 978-3-030-55034-9.
- ↑ "AVEO Releases Phase 2 Data", Drug Discovery & Development: dddmag.com, May 3, 2012, http://www.dddmag.com/news/2012/05/aveo-releases-phase-2-data, retrieved June 3, 2012
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