Biology:3-phytase
The enzyme 3-phytase (EC 3.1.3.8) catalyzes the reaction
- REDIRECT Template:Chemical reaction
The enzyme characterised from Aspergillus ficuum hydrolyses phytic acid to inositol pentakisphosphate and orthophosphate.[1][2] A genetically modified form of the enzyme has been evaluated for its safety in food manufacture.[3]
These enzymes belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name myo-inositol-hexakisphosphate 3-phosphohydrolase. Other names in common use include 1-phytase, phytate 1-phosphatase, phytate 3-phosphatase, and phytate 6-phosphatase.[4]
Enzymes of this type participate in inositol phosphate metabolism.
Structural studies
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1CVM, 1IHP, 1POO, 1QFX, 1QLG, 1QWO, 1SK8, 1SK9, 1SKA, 1SKB, 2GFI, and 2POO.
See also
- 4-phytase (6-phytase)
- 5-phytase
- Protein tyrosine phosphatase
References
- ↑ Irving, G. C. J.; Cosgrove, D. J. (1972). "Inositol Phosphate Phosphatases of Microbiological Origin: The Inositol Pentaphosphate Products of Aspergillus ficuum Phytases". Journal of Bacteriology 112 (1): 434–438. doi:10.1128/JB.112.1.434-438.1972. PMID 4342816.
- ↑ "The term phytase comprises several different classes of enzymes". Biochemical and Biophysical Research Communications 312 (1): 179–84. December 2003. doi:10.1016/j.bbrc.2003.09.176. PMID 14630039. Bibcode: 2003BBRC..312..179M.
- ↑ Lambré, Claude; Barat Baviera, José Manuel; Bolognesi, Claudia et al. (2024). "Safety evaluation of the food enzyme 3-phytase from the genetically modified Aspergillus niger strain NPH". EFSA Journal 22 (1). doi:10.2903/j.efsa.2024.8514. PMID 38222927.
- ↑ Enzyme 3.1.3.8 at KEGG Pathway Database.
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