Biology:5-phytase
The enzyme 5-phytase (EC 3.1.3.72) catalyzes the reaction
- REDIRECT Template:Chemical reaction
The enzyme characterised from Lilium longiflorum pollen hydrolyses phytic acid (myo-inositol hexakisphosphate) to 1L-myo-inositol 1,2,3,4,6-pentakisphosphate and orthophosphate (Pi). Mechanistically, this is a histidine acid phosphatase.[1][2] A protein tyrosine phosphatase-like phytase from Selenomonas ruminantium subsp. lactilytica has also been described. Both are specific for the 5-phosphate position of myo-inositol hexakisphosphate.[3][4]
This enzyme is a hydrolase, specifically one acting on phosphoric monoester bonds. The systematic name of this enzyme class is myo-inositol-hexakisphosphate 5-phosphohydrolase.[5]
Structural studies
As of late 2007, only the phytase purified from lily pollen had its structure solved, with PDB accession codes 1U24, 1U25, 1U26, 2B4O, 2B4P, and 2B4U.
See also
- 3-phytase (1-phytase)
- 4-phytase (6-phytase)
- Protein tyrosine phosphatase
References
- ↑ "Specificity of hydrolysis of phytic acid by alkaline phytase from lily pollen". Plant Physiology 106 (4): 1489–1495. 1994. doi:10.1104/pp.106.4.1489. PMID 7846160.
- ↑ Gocheva, Yana; Engibarov, Stephan; Lazarkevich, Irina; Eneva, Rumyana (2023). "Phytases - Types, Sources, and Factors Affecting Their Activity". Acta Microbiologica Bulgaria 39 (3). https://www.academia.edu/download/106743898/24_AMB_39_3_Article_05.pdf.
- ↑ "A protein tyrosine phosphatase-like inositol polyphosphatase from Selenomonas ruminantium subsp. lactilytica has specificity for the 5-phosphate of myo-inositol hexakisphosphate". The International Journal of Biochemistry & Cell Biology 40 (10): 2053–2064. 2008. doi:10.1016/j.biocel.2008.02.003. PMID 18358762.
- ↑ Nezhad, Nima Ghahremani; Rahman, Raja Noor Zaliha Raja Abd; Normi, Yahaya M.; Oslan, Siti Nurbaya; Shariff, Fairolniza Mohd; Leow, Thean Chor (2023). "Isolation, screening and molecular characterization of phytase-producing microorganisms to discover the novel phytase". Biologia 78 (9): 2527–2537. doi:10.1007/s11756-023-01391-w.
- ↑ Enzyme 3.1.3.72 at KEGG Pathway Database.
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