Biology:Leukocyte receptor tyrosine kinase
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Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.[1][2]
Function
The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown.[3] Closely related to the insulin receptor family of RTKs. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]
Interactions
LTK has been shown to interact with IRS-1, Shc, and PIK3R1.[4][5]
References
- ↑ "Human ltk: gene structure and preferential expression in human leukemic cells". Oncogene Res 5 (3): 199–204. May 1990. PMID 2320375.
- ↑ 2.0 2.1 "Entrez Gene: LTK leukocyte tyrosine kinase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4058.
- ↑ "Leukocyte tyrosine kinase functions in pigment cell development". PLOS Genet. 4 (3): e1000026. 2008. doi:10.1371/journal.pgen.1000026. PMID 18369445.
- ↑ "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene 9 (10): 2991–8. October 1994. PMID 8084603.
- ↑ "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene 14 (25): 3067–72. June 1997. doi:10.1038/sj.onc.1201153. PMID 9223670.
Further reading
- "The ltk gene encodes a novel receptor-type protein tyrosine kinase.". EMBO J. 10 (10): 2911–9. 1991. doi:10.1002/j.1460-2075.1991.tb07841.x. PMID 1655406.
- "Identification and chromosomal mapping of new human tyrosine kinase genes.". Oncogene 5 (3): 277–82. 1990. PMID 2156206.
- "Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain.". Nature 333 (6174): 672–6. 1988. doi:10.1038/333672a0. PMID 2836739. Bibcode: 1988Natur.333..672B.
- "Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein.". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5404–8. 1993. doi:10.1073/pnas.90.12.5404. PMID 7685902. Bibcode: 1993PNAS...90.5404T.
- "Regional localization of human chromosome 15 loci.". Genomics 23 (3): 619–27. 1995. doi:10.1006/geno.1994.1550. PMID 7851890.
- "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo.". Oncogene 9 (10): 2991–8. 1994. PMID 8084603.
- "Identification of the human ltk gene product in placenta and hematopoietic cell lines.". Biochem. Biophys. Res. Commun. 190 (2): 674–9. 1993. doi:10.1006/bbrc.1993.1101. PMID 8427607.
- "Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase.". J. Biol. Chem. 271 (44): 27707–14. 1996. doi:10.1074/jbc.271.44.27707. PMID 8910363.
- "A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin.". J. Biol. Chem. 272 (2): 1297–301. 1997. doi:10.1074/jbc.272.2.1297. PMID 8995435.
- "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.". Oncogene 14 (25): 3067–72. 1997. doi:10.1038/sj.onc.1201153. PMID 9223670.
- "The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.". Protein Sci. 11 (10): 2326–34. 2003. doi:10.1110/ps.0213402. PMID 12237455.
- "Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.". Hum. Mol. Genet. 13 (2): 171–9. 2004. doi:10.1093/hmg/ddh020. PMID 14695357.
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