Biology:Retagliptin

Retagliptin
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name Methyl 7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1-carboxylate;
CAS Number	1174122-54-3;
PubChem CID	44193830;
DrugBank	DB14898;
ChemSpider	57583801;
UNII	328C4R3P9L;
ChEMBL	ChEMBL4297435;
Chemical and physical data
Formula	C19H18F6N4O3
Molar mass	464.368 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC(=O)C1=C2CN(CCN2C(=N1)C(F)(F)F)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N;
	InChI InChI=1S/C19H18F6N4O3/c1-32-17(31)16-14-8-28(2-3-29(14)18(27-16)19(23,24)25)15(30)6-10(26)4-9-5-12(21)13(22)7-11(9)20/h5,7,10H,2-4,6,8,26H2,1H3/t10-/m1/s1; Key:WIIAMRXFUJLYEF-SNVBAGLBSA-N;

Short description: Chemical compound

Retagliptin is a DPP-4 inhibitor studied for the treatment of type 2 diabetes.^[1]^[2]^[3]

Refences

↑ Meng, Xiangjun; Cai, Lanlan; Ren, Tianming; Sun, Dong; Gu, Jingkai (2018). "Simultaneous quantitative analysis of retagliptin and its main active metabolite in human multiple matrices by liquid chromatography tandem mass spectrometry" (in en). Analytical Methods 10 (18): 2108–2114. doi:10.1039/C8AY00040A. ISSN 1759-9679. https://pubs.rsc.org/en/content/articlelanding/2018/ay/c8ay00040a.
↑ Hu, Chao; Zheng, Jing; Miao, Jia; Liu, Fang; Hu, Ting-Ting; Gu, Jing-Kai; Shu, Shi-Qing; Wang, Ying et al. (2018). "[Pharmacokinetics of Phosphate Retagliptin Tabletin in Patients with Renal Dysfunction"]. Sichuan da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition 49 (1): 74–80. ISSN 1672-173X. PMID 29737094. https://pubmed.ncbi.nlm.nih.gov/29737094/.
↑ Cahn, Avivit; Cernea, Simona; Raz, Itamar (2016). "An update on DPP-4 inhibitors in the management of type 2 diabetes". Expert Opinion on Emerging Drugs 21 (4): 409–419. doi:10.1080/14728214.2016.1257608. PMID 27809608.

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Legal status

Legal status	Investigational
Identifiers
IUPAC name Methyl 7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1-carboxylate
CAS Number	1174122-54-3
PubChem CID	44193830
DrugBank	DB14898
ChemSpider	57583801
UNII	328C4R3P9L
ChEMBL	ChEMBL4297435
Chemical and physical data
Formula	C₁₉H₁₈F₆N₄O₃
Molar mass	464.368 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COC(=O)C1=C2CN(CCN2C(=N1)C(F)(F)F)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N
InChI InChI=1S/C19H18F6N4O3/c1-32-17(31)16-14-8-28(2-3-29(14)18(27-16)19(23,24)25)15(30)6-10(26)4-9-5-12(21)13(22)7-11(9)20/h5,7,10H,2-4,6,8,26H2,1H3/t10-/m1/s1 Key:WIIAMRXFUJLYEF-SNVBAGLBSA-N