Chemistry:Brodimoprim

Brodimoprim
Clinical data
ATC code	J01EA02 (WHO) ;
Identifiers
	IUPAC name 5-[(4-Bromo-3,5-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine;
CAS Number	56518-41-3 ;
PubChem CID	68760;
ChemSpider	62004 ;
UNII	V1YC7T6LLI;
KEGG	D07238 ;
ChEBI	CHEBI:131726;
ChEMBL	ChEMBL31891 ;
Chemical and physical data
Formula	C13H15BrN4O2
Molar mass	339.193 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	225 to 228 °C (437 to 442 °F)
	SMILES Brc1c(OC)cc(cc1OC)Cc2cnc(nc2N)N;
	InChI InChI=1S/C13H15BrN4O2/c1-19-9-4-7(5-10(20-2)11(9)14)3-8-6-17-13(16)18-12(8)15/h4-6H,3H2,1-2H3,(H4,15,16,17,18) ; Key:BFCRRLMMHNLSCP-UHFFFAOYSA-N ;
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Short description: Chemical compound

Brodimoprim is a structural derivative of trimethoprim. In brodimoprim, the 4-methoxy group of trimethoprim is replaced with a bromine atom.

As trimethoprim, brodimoprim is a selective inhibitor of bacterial dihydrofolate reductase.^[1]

References

↑ "Trimethoprim and brodimoprim resistance of gram-positive and gram-negative bacteria". Journal of Chemotherapy 5 (6): 458–64. December 1993. doi:10.1080/1120009X.1993.11741096. PMID 8195838.

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Clinical data

ATC code	J01EA02 (WHO)
Identifiers
IUPAC name 5-[(4-Bromo-3,5-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine
CAS Number	56518-41-3^Y
PubChem CID	68760
ChemSpider	62004^Y
UNII	V1YC7T6LLI
KEGG	D07238^Y
ChEBI	CHEBI:131726
ChEMBL	ChEMBL31891^Y
Chemical and physical data
Formula	C₁₃H₁₅BrN₄O₂
Molar mass	339.193 g·mol⁻¹
3D model (JSmol)	Interactive image
Melting point	225 to 228 °C (437 to 442 °F)
SMILES Brc1c(OC)cc(cc1OC)Cc2cnc(nc2N)N
InChI InChI=1S/C13H15BrN4O2/c1-19-9-4-7(5-10(20-2)11(9)14)3-8-6-17-13(16)18-12(8)15/h4-6H,3H2,1-2H3,(H4,15,16,17,18)^Y Key:BFCRRLMMHNLSCP-UHFFFAOYSA-N^Y
(verify)