Chemistry:Sulfadoxine
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Short description: Chemical compound
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| Formula | C12H14N4O4S |
| Molar mass | 310.33 g·mol−1 |
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| Melting point | 190 to 194 °C (374 to 381 °F) |
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Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria.[1]
It is also used to prevent malaria[2] but due to high levels of sulphadoxine-pyrimethamine resistance, this use has become less common.[3]
It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.[citation needed]
Mechanism of action
Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.[citation needed]
See also
- Sulfadoxine/pyrimethamine
References
- ↑ Medical Treatment - Sulphadoxine and Pyrimethamine .
- ↑ "WHO | Intermittent preventive treatment in pregnancy (IPTp)". http://www.who.int/malaria/areas/preventive_therapies/pregnancy/en/.
- ↑ "High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania.". Malar J 13: 152. 2014. doi:10.1186/1475-2875-13-152. PMID 24751352.
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