Chemistry:Sulfalene
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Short description: Chemical used to treat pulmonary issues
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| Clinical data | |
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| Trade names | Eadazine, Kelfizina, Kelfizine W, Longum |
| Other names | Sulfametopyrazine |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral[1] |
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| Pharmacokinetic data | |
| Protein binding | 60 to 80%[1] |
| Elimination half-life | 60 to 65 hours[1] |
| Excretion | Urinary[1] |
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| Chemical and physical data | |
| Formula | C11H12N4O3S |
| Molar mass | 280.30 g·mol−1 |
| 3D model (JSmol) | |
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Sulfalene (INN, USAN) or sulfametopyrazine (BAN) is a long-acting sulfonamide antibacterial used for the treatment of chronic bronchitis, urinary tract infections and malaria.[2][3] As of 2014 there were only two countries in which it is currently still marketed: Thailand and Ireland.[3]
It was discovered by researchers at Farmitalia and first published in 1960 and was marketed as Kelfizina.[4][5]
See also
References
- ↑ 1.0 1.1 1.2 1.3 "Sulfalene". MIMS Drug Information System. http://www.cimsasia.com/USA/drug/info/sulfalene/?q=Sulphonamides&type=full.
- ↑ DrugBank DB00664
- ↑ 3.0 3.1 "Sulfametopyrazine". Martindale: The Complete Drug Reference. Pharmaceutical Press. 9 May 2013. http://www.medicinescomplete.com/mc/martindale/current/4920-k.htm.
- ↑ "Clinical trials in Plasmodium falciparum malaria with a long-acting sulphonamide". Transactions of the Royal Society of Tropical Medicine and Hygiene 60 (2): 222–4. 1966. doi:10.1016/0035-9203(66)90030-7. PMID 5332105.
- ↑ Per prior citation, the first publication: "Derivati della parazina II. Sulfonamdopir" (in it). Gazz Chim Ital 90: 1802–1815. 1960.
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