Chemistry:Furoxan
From HandWiki
Furoxan (1,2,5-oxadiazole 2-oxide) is a heterocycle of the isoxazole family and an amine oxide derivative of furazan. It is a nitric oxide donor.[1] As such, furoxan and its derivatives, such as ipramidil or 3,4-dicyanofuroxan, are being actively studied as potential new drugs[2] and insensitive high density explosives (4,4'-Dinitro-3,3'-diazenofuroxan).
Furoxanes can be formed by dimerization of nitrile oxides.
References
- ↑ Clara Cena; Massimo Bertinaria; Donatella Boschi; Marta Giorgis; Alberto Gasco (2006). "Use of the furoxan (1,2,5-oxadiazole 2-oxide) system in the design of new NO-donor antioxidant hybrids". Arkivoc (HL-1787GR): 301–309. http://www.arkat-usa.org/ark/journal/2006/I07_ICHC-20/1787/HL-1787GR%20as%20published%20mainmanuscript.pdf.
- ↑ I.N. Kolesnikova; S.V. Kolesnikov; N.V. Lobanov; P.Yu. Sharanov; A.A. Larin; F.E. Teslenko; L.L. Fershtat; I.F. Shishkov (2023). "Molecular structure of 3,4-dicyanofuroxan studied by gas electron diffraction. Application of DFT theory and coupled cluster computations". Chemical Physics Letters (829): 140770. https://doi.org/10.1016/j.cplett.2023.140770.
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