Chemistry:Dihydropyridine

Dihydropyridine

Names
Systematic IUPAC name 1,4-Dihydropyridine
Identifiers
CAS Number	3337-17-5 Y
3D model (JSmol)	Interactive image
ChemSpider	94619 Y
MeSH	1,4-dihydropyridine
PubChem CID	104822
UNII	7M8K3P6I89 Y
InChI InChI=1S/C5H7N/c1-2-4-6-5-3-1/h2-6H,1H2 Y Key: YNGDWRXWKFWCJY-UHFFFAOYSA-N Y
SMILES C1C=CNC=C1
Properties
Chemical formula	C5H7N
Molar mass	81.1158 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Tracking categories (test):

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Dihydropyridine (DHP) is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure.

Class members

Dihydropyridine class L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries):

Name	Image	Brand name
Amlodipine		Norvasc, Istin, Normodipine, Tenox, Cordi Cor
Aranidipine		Sapresta (サプレスタ)
Azelnidipine		CalBlock (カルブロック)
Barnidipine		Vasexten, Libradin, Cyress, HypoCa
Benidipine		Coniel
Cilnidipine		Atelec (アテレック), Cilacar, Cinalong, Siscard
Clevidipine		Cleviprex
Cronidipine
Darodipine
Dexniguldipine
Efonidipine		Landel (ランデル)
Elgodipine
Elnadipine
Felodipine		Renedil, Plendil
Flordipine
Furnidipine
Iganidipine
Isradipine		DynaCirc CR
Lacidipine		Lacipil, Motens, Sakure
Lemildipine
Lercanidipine		Zanidip, Zanidip-Recordati
Levamlodipine		EsCordi Cor
Levniguldipine
Manidipine		Manyper, Caslot, Madipine
Nicardipine		Cardene, Cardene SR
Nifedipine		Adalat, Nifedical, Procardia, Corinfar, Cordaflex
Niguldipine
Niludipine
Nilvadipine		Nivadil
Nimodipine		Nimotop
Nisoldipine		Sular, Baymycard, Syscor
Nitrendipine		Baypress, Cardif, Nitrepin, Baylotensin
Olradipine
Oxodipine
Palonidipine
Pranidipine		Acalas
Ryodipine
Sagandipine
Sornidipine
Teludipine
Tiamdipine
Trombodipine
Vatanidipine

The pharmaceutical drug finerenone is also a dihydrophyridine derivative, but does not act as a calcium channel blocker but as an antimineralocorticoid.

See also

• Calcium channel blocker (including section on non-dihydropyridine calcium channel blockers)
• Calcium channel
• Dihydropyridine receptor

External links

• Dihydropyridines at the US National Library of Medicine Medical Subject Headings (MeSH)