Chemistry:Gatipotuzumab

From HandWiki
Short description: Monoclonal antibody
Gatipotuzumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized (from mouse)
Targettumor specific glycosylation of MUC1
Clinical data
Other namesPankoMab-GEX, anti-TA-MUC1
ATC code
  • None
Identifiers
CAS Number
ChemSpider
  • none
UNII

Gatipotuzumab is a humanized monoclonal antibody recognizing the tumor-specific epitope of mucin-1 (TA-MUC1), enabling it to differentiate between tumor MUC1 and non-tumor MUC1 epitopes.[1] Gatipotuzumab is being developed by Glycotope GMBH [2] and is undergoing a phase II clinical trial for ovarian cancer.[3]

References

  1. "Gatipotuzumab". Drug Dictionary. National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services. http://www.cancer.gov/drugdictionary?cdrid=687630. 
  2. "Gatipotuzumab – Our first-in-class GlycoBody against the novel tumor-specific TA-MUC1 epitope". Glycotope GmbH. https://www.glycotope.com/pipeline/pankomab-gex. 
  3. Clinical trial number NCT01899599 for "PankoMab-GEX™ Versus Placebo as Maintenance Therapy in Advanced Ovarian Cancer " at ClinicalTrials.gov

External links