Chemistry:Prosultiamine
From HandWiki
Short description: Chemical compound
 | |
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
| ATC code |
|
| Legal status | |
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| Chemical and physical data | |
| Formula | C15H24N4O2S2 |
| Molar mass | 356.50 g·mol−1 |
| 3D model (JSmol) | |
| |
Prosultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is a homolog of allithiamine. It was developed as a treatment for vitamin B1 deficiency.[1][2] [3] It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.[4][5]
Research
It has been studied as a potential treatment for infection with human T-lymphotropic virus (HTLV), since it has been shown to reduce viral load and symptoms.[6]
See also
References
- ↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
- ↑ Dictionary of pharmacological agents. London: Chapman & Hall. 1997. ISBN 0-412-46630-9.
- ↑ ""allithiamine" A Newly Found Derivative of Vitamin B1". The Journal of Biochemistry 41: 29–39. 1954. doi:10.1093/oxfordjournals.jbchem.a126421.
- ↑ "Thiamine propyl disulfide: absorption and utilization". Annals of Internal Medicine 74 (4): 529–534. April 1971. doi:10.7326/0003-4819-74-4-529. PMID 5551161.
- ↑ "Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines". Journal of Nutritional Science and Vitaminology 22 SUPPL: 63–68. August 1976. doi:10.3177/jnsv.22.supplement_63. PMID 978282.
- ↑ "Nervous System Disease: A New Outlet for an Old Drug?". Science Daily. 15 August 2013. https://www.sciencedaily.com/releases/2013/08/130815084757.htm.
 |  |
