Chemistry:Tocofersolan
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| IUPAC name
α-Hydro-ω-{[4-oxo-4-({(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl}oxy)butanoyl]oxy}poly(oxyethylene)
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| Other names
Tocofersolan; Vitamin E PEG succinate; α-Tocopherol polyethylene glycol succinate (TPGS); Liqui-E
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| (C2H4O)nC33H54O5 | |
| Molar mass | Variable |
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| 1=ATC code }} | A11HA08 (WHO) |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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| Clinical data | |
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| Trade names | Vedrop |
| Other names | Tocophersolan (USAN US) |
| AHFS/Drugs.com | UK Drug Information |
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Tocofersolan (INN) or tocophersolan, also referred to as TPGS (for tocopherol polyethylene glycol succinate), is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is polyethylene glycol derivative of α-tocopherol that enables water solubility.
Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease.[3] On 24 July 2009 the European Medicines Agency approved tocofersolan under the trade name Vedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestive malabsorption in paediatric patients with congenital or hereditary chronic cholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region).[4]
Tocofersolan is also used in cosmetics and pharmaceuticals as an antioxidant.[5]
References
- ↑ "Vedrop 50 mg/ml oral solution - Summary of Product Characteristics (SmPC)". 19 June 2019. https://www.medicines.org.uk/emc/product/5949/smpc.
- ↑ "Vedrop EPAR". https://www.ema.europa.eu/en/medicines/human/EPAR/vedrop.
- ↑ "Tocophersolan Oral". WebMD. http://www.webmd.com/drugs/drug-149234-Tocophersolan+Oral.aspx?drugid=149234&drugname=Tocophersolan+Oral.
- ↑ "Vedrop Summary of Product Characteristics". European Medicines Agency. http://www.ema.europa.eu/humandocs/PDFs/EPAR/vedrop/emea-combined-h920en.pdf.
- ↑ Handbook of Preservatives. Synapse Info Resources. 2004. p. 568. ISBN 1-890595-66-7.
External links
- "Tocophersolan". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/name/tocophersolan.
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