Chemistry:Toceranib
From HandWiki
Short description: Chemical compound used in the treatment of tumors
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| Trade names | Palladia |
| AHFS/Drugs.com | Veterinary Use |
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| Routes of administration | By mouth |
| Drug class | Antineoplastic agent |
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| Bioavailability | 77% |
| Protein binding | 91%-93% |
| Elimination half-life | 16 h |
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| Formula | C22H25FN4O2 |
| Molar mass | 396.466 g·mol−1 |
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Toceranib is a receptor tyrosine kinase inhibitor and is used in the treatment[1] of canine mast cell tumor also called mastocytoma. Together with masitinib (Kinavet (US)/Masivet (EU/ROW) by AB Science), toceranib is the only dog-specific anti-cancer drug[2] approved by the U.S. Food and Drug Administration (FDA).[3][4] It is sold under the brand name Palladia as its phosphate salt, toceranib phosphate (INN) by Pfizer. It was developed by SUGEN as SU11654,[5] a sister compound to sunitinib, which was later approved for human therapies. Toceranib is likely to act mostly through inhibition of the kit tyrosine kinase, though it may also have an anti-angiogenic effect.
References
- ↑ "Multi-center, Placebo-controlled, Double-blind, Randomized Study of Oral Toceranib Phosphate (SU11654), a Receptor Tyrosine Kinase Inhibitor, for the Treatment of Dogs with Recurrent (Either Local or Distant) Mast Cell Tumor Following Surgical Excision.". Clin Cancer Res 15 (11): 3856–65. June 2009. doi:10.1158/1078-0432.CCR-08-1860. PMID 19470739. http://clincancerres.aacrjournals.org/cgi/content/abstract/15/11/3856.
- ↑ CBS News FDA Approves First-Ever Dog Cancer Drug
- ↑ "FDA: First Drug to Treat Cancer in Dogs Approved". U.S. Food and Drug Administration (FDA) (Press release). 3 June 2009. Archived from the original on 22 July 2010. Retrieved 2 October 2021.
- ↑ "Palladia New Animal Drug Application". 22 May 2009. http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM164091.pdf.
- ↑ "In Trials for New Cancer Drugs, Family Pets Are Benefiting, Too". 24 November 2006. https://www.nytimes.com/2006/11/24/business/24cancer.html.
External links
- "Toceranib". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/name/toceranib.
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