Chemistry:Denileukin diftitox
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Short description: Pharmaceutical drug
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| Trade names | Ontak |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a611024 |
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| Routes of administration | Intravenous |
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| Elimination half-life | 70-80 min |
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| Formula | C2560H4042N678O799S17 |
| Molar mass | 57647.46 g·mol−1 |
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Denileukin diftitox (trade name Ontak) was an antineoplastic agent, an engineered protein combining interleukin-2 and diphtheria toxin. Denileukin diftitox could bind to interleukin-2 receptors[1] and introduce the diphtheria toxin into cells that express those receptors, killing the cells. In some leukemias and lymphomas, malignant cells express these receptors, so denileukin diftitox can target these.
In 1999, Ontak was approved by the U.S. Food and Drug Administration (FDA) for treatment of Cutaneous T-cell lymphoma (CTCL).[2]
There is some evidence tying it to vision loss, and in 2006 the FDA added a black box warning to the drug's label.[3]
In 2014, marketing of Ontak was discontinued in the US.[4]
References
- ↑ "Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders". Expert Review of Anticancer Therapy 7 (1): 11–7. January 2007. doi:10.1586/14737140.7.1.11. PMID 17187516.
- ↑ "Denileukin diftitox: a novel immunotoxin". Expert Opinion on Biological Therapy 9 (11): 1445–51. November 2009. doi:10.1517/14712590903348135. PMID 19817678.
- ↑ "Role of denileukin diftitox in the treatment of persistent or recurrent cutaneous T-cell lymphoma". Cancer Management and Research 2: 53–9. February 2010. doi:10.2147/cmar.s5009. PMID 21188096.
- ↑ "FDA Drug Shortages". U.S. Food and Drug Administration. 31 January 2014. https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Denileukin+Diftitox+%28Ontak%29+Injection&st=d&tab=tabs-2.
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