Chemistry:UMB66

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UMB66
3-chloropropionic acid.svg
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC3H5ClO2
Molar mass108.52 g/mol g·mol−1
3D model (JSmol)
Melting point42 °C (108 °F)
Boiling point204 °C (399 °F) (decomp.)
  (verify)

3-Chloropropanoic acid (also 3-chloropropionic acid) or UMB66 is a drug used in scientific research. It is structurally related to GHB and binds to the GHB receptor, but has no affinity for GABA receptors.[1] It is also an active ingredient in some herbicide blends.[2] Overdose may cause unconsciousness and/or convulsions.[3]

References

  1. Macias, A. T.; Hernandez, R. J.; Mehta, A. K.; MacKerell, A. D. Jr; Ticku, M. K.; Coop, A. (2004). "3-Chloropropanoic acid (UMB66): A ligand for the gamma-hydroxybutyric acid receptor lacking a 4-hydroxyl group". Bioorganic & Medicinal Chemistry 12 (7): 1643–1647. doi:10.1016/j.bmc.2004.01.025. PMID 15028257. 
  2. Ng, H. J.; Ab. Wahab, R.; Cooper, R. A.; Huyop, F. (2005). "Degradation Of Herbicide (3-Chloropropionic Acid) By Bacterial Dehalogenases" (pdf). Proc. KUSTEM 4th Annual Seminar 2005: 586–590. Archived from the original on 2016-03-05. https://web.archive.org/web/20160305055537/http://eprints.utm.my/1748/2/FZH.pdf. 
  3. "Chemical Data Sheet for 3-CHLOROPROPIONIC ACID". NOAA. http://cameochemicals.noaa.gov/chemical/10304.