Chemistry:Nipecotic acid
From HandWiki
Short description: Chemical compound
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| Formula | C6H11NO2 |
| Molar mass | 129.159 g·mol−1 |
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Nipecotic acid is a GABA reuptake inhibitor used in scientific research.[1][2][3] It has very little to no blood–brain barrier penetration itself, but structural modifications have been made to improve this.[4][5]
See also
References
- ↑ Antiepileptic drugs: pharmacology and therapeutics (First ed.). [S.l.]: Springer. 2012. p. 130. ISBN 978-3-642-64244-9. "In contrast, prolonged (1 h) exposure to gabapentin enhanced the shunting effect on CAl region excitatory postsynaptic potentials induced by the GABA uptake inhibitor, nipecotic acid, which promotes GABA release."
- ↑ "Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina". The Japanese Journal of Physiology 45 (3): 457–473. 1995. doi:10.2170/jjphysiol.45.457. PMID 7474528.
- ↑ "Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures". Epilepsy Research 86 (2–3): 113–123. October 2009. doi:10.1016/j.eplepsyres.2009.05.008. PMID 19535226.
- ↑ Shek, Efraim (1994). "Chemical delivery systems and prodrugs of anticonvulsive drugs". Advanced Drug Delivery Reviews 14 (2–3): 227–241. doi:10.1016/0169-409X(94)90041-8. "Nipecotic acid is a potent in vitro inhibitor of neuronal and glial GABA uptake. However, because nipecotic acid does not penetrate the blood-brain barrier (BBB) it lacks any in vivo activity [23,24].".
- ↑ "Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug". Drug Research 71 (2): 94–103. February 2021. doi:10.1055/a-1290-0119. PMID 33241549.
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