Chemistry:Luseogliflozin
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| Trade names | Lusefi |
| Other names | TS-071 |
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| Formula | C23H30O6S |
| Molar mass | 434.55 g·mol−1 |
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Luseogliflozin (trade name Lusefi) is a pharmaceutical drug (an SGLT2 inhibitor) used for the treatment of type 2 diabetes mellitus.[1][2] It was approved for use in Japan in 2014.[1] In a meta-analysis involving data from 10 randomized controlled trials (1304 patients), Dutta et. al. demonstrated the good glycaemic efficacy (mean glycated hemoglobin reduction of -0.76% and mean fasting glucose reduction of -26.69mg/dl) and safety of luseogliflozin 2.5mg/day as compared to placebo. Additional benefits include significant reduction in systolic blood pressure (-4.19 mm Hg), serum triglycerides (-12.60mg/dl), uric acid (-0.48mg/dl) and alanine aminotransferase (-4.11 IU/L) as compared to placebo, highlighting the beneficial impact on the different aspects of metabolic syndrome. [3]
References
- ↑ 1.0 1.1 "Luseogliflozin: first global approval". Drugs 74 (8): 945–50. June 2014. doi:10.1007/s40265-014-0230-8. PMID 24848756.
- ↑ "Luseogliflozin, an SGLT2 Inhibitor, in Japanese Patients With Mild/Moderate Hepatic Impairment: A Pharmacokinetic Study". Clinical Pharmacology in Drug Development 6 (5): 439–447. September 2017. doi:10.1002/cpdd.364. PMID 28783873.
- ↑ "Efficacy and safety of luseogliflozin in improving glycaemic and non-glycaemic outcomes in type-2 diabetes: A meta-analysis.". Diabetes Metab Syndr 17 (3): 102742. Mar 2023. doi:10.1016/j.dsx.2023.102742. PMID 36933330.
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