Biology:ACVR1
 Generic protein structure example |
Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ACVR1 gene; also known as ALK-2 (activin receptor-like kinase-2).[1] ACVR1 has been linked to the 2q23-24 region of the genome.[2] This protein is important in the bone morphogenic protein (BMP) pathway which is responsible for the development and repair of the skeletal system. While knock-out models with this gene are in progress, the ACVR1 gene has been connected to fibrodysplasia ossificans progressiva, an extremely rare progressive genetic disease characterized by heterotopic ossification of muscles, tendons and ligaments.[3] It is a bone morphogenetic protein receptor, type 1.
Function
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.[4]
Signaling
ACVR1 transduces signals of BMPs. BMPs bind either ACVR2A/ACVR2B or a BMPR2 and then form a complex with ACVR1. These go on to recruit the R-SMADs SMAD1, SMAD2, SMAD3 or SMAD6.[5]
Clinical significance
Gain-of-function mutations in the gene ACVR1/ALK2 is responsible for the genetic disease fibrodysplasia ossificans progressiva.[6] The typical FOP patient has the amino acid arginine substituted for the amino acid histidine at position 206 in this protein.[6][7] This causes a change in the critical glycine-serine activation domain of the protein which will cause the protein to bind its inhibitory ligand (FKBP12) less tightly, and thus over-activate the BMP/SMAD pathway.[2] The result of this over-activation is that endothelial cells transform to mesenchymal stem cells and then to bone.[8] Atypical mutations involving other residues work similarly - causing the protein to be stuck in its active conformation despite no BMP being present.[9]
Mutations in the ACVR1 gene have also been linked to cancer, especially diffuse intrinsic pontine glioma (DIPG).[10][11][12]
References
- ↑ "Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity". Oncogene 8 (10): 2879–87. October 1993. PMID 8397373.
- ↑ 2.0 2.1 "Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons". Pediatr Endocrinol Rev 10 Suppl 2 (2): 437–48. June 2013. PMID 23858627.
- ↑ "Fibrodysplasia Ossificans Progressiva: What Have We Achieved and Where Are We Now? Follow-up to the 2015 Lorentz Workshop". Front Endocrinol (Lausanne) 12: 732728. 2021. doi:10.3389/fendo.2021.732728. PMID 34858325.
- ↑ "Entrez Gene: ACVR1 (activin A receptor, type I)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90.
- ↑ "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Molecular Pharmacology 62 (1): 65–74. July 2002. doi:10.1124/mol.62.1.65. PMID 12065756.
- ↑ 6.0 6.1 "A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva". Nature Genetics 38 (5): 525–7. May 2006. doi:10.1038/ng1783. PMID 16642017.
- ↑ "News Release of FOP's Cause". http://www.uphs.upenn.edu/news/News_Releases/apr06/FOP.htm.
- ↑ "ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation". Journal of Bone and Mineral Research 25 (6): 1208–15. June 2010. doi:10.1359/jbmr.091110. PMID 19929436.
- ↑ "Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients". PLOS ONE 4 (3): e5005. 2009. doi:10.1371/journal.pone.0005005. PMID 19330033. Bibcode: 2009PLoSO...4.5005P.
- ↑ "Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma". Nature Genetics 46 (5): 457–61. May 2014. doi:10.1038/ng.2925. PMID 24705252.
- ↑ "Cure Brain Cancer - News - Multiple Breakthroughs in Childhood Brain Cancer DIPG". Cure Brain Cancer Foundation. http://www.curebraincancer.org.au/news/1044/multiple-breakthroughs-in-childhood-brain-cancer.
- ↑ "Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations". Nature Genetics 46 (5): 451–6. May 2014. doi:10.1038/ng.2936. PMID 24705254.
External links
- Human ACVR1 genome location and ACVR1 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: Q04771 (Human Activin receptor type-1) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
