Biology:Multiple inositol-polyphosphate phosphatase
From HandWiki
| multiple inositol-polyphosphate phosphatase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.1.3.62 | ||||||||
| CAS number | 116958-30-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme multiple inositol-polyphosphate phosphatase (EC 3.1.3.62) catalyzes the reaction
- myo-inositol hexakisphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] myo-inositol pentakisphosphate (mixed isomers) + phosphate
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is 1D-myo-inositol-hexakisphosphate 5-phosphohydrolase. Other names in common use include inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase, inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase, inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase, inositol tetrakisphosphate phosphomonoesterase, inositol-1,3,4,5-tetrakisphosphate 3-phosphatase, and MIPP. This enzyme participates in inositol phosphate metabolism.
References
- "Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate". Biochem. J. 259 (3): 931–3. 1989. PMID 2786415.
- "Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase". Biochem. J. 328: 75–81. PMID 9359836.
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