Chemistry:FGI-106

FGI-106
Legal status
Legal status	US: Investigational New Drug ;
Identifiers
	IUPAC name N1,N7-bis[3-(dimethylamino)propyl]-3,9-dimethylquinolino[8,7-h]quinoline-1,7-diamine;
CAS Number	501081-38-5 ;
PubChem CID	432342;
ChemSpider	382357;
UNII	BRT994456W;
Chemical and physical data
Formula	C28H38N6
Molar mass	458.654 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCCNc(c2ccc14)cc(C)nc2c1ccc3c4nc(C)cc3NCCCN(C)C;
	InChI InChI=1S/C28H38N6/c1-19-17-25(29-13-7-15-33(3)4)23-11-10-22-21(27(23)31-19)9-12-24-26(18-20(2)32-28(22)24)30-14-8-16-34(5)6/h9-12,17-18H,7-8,13-16H2,1-6H3,(H,29,31)(H,30,32); Key:WJUPENLNVUCETH-UHFFFAOYSA-N;

Short description: Chemical compound

FGI-106 is a broad-spectrum antiviral drug developed as a potential treatment for enveloped RNA viruses, in particular viral hemorrhagic fevers from the bunyavirus, flavivirus and filovirus families. It acts as an inhibitor which blocks viral entry into host cells. In animal tests FGI-106 shows both prophylactic and curative action against a range of deadly viruses for which few existing treatments are available, including the bunyaviruses hantavirus, Rift Valley fever virus and Crimean-Congo hemorrhagic fever virus, the flavivirus dengue virus, and the filoviruses Ebola virus and Marburg virus.^[1]^[2]^[3]^[4]^[5]

References

↑ "Development of a broad-spectrum antiviral with activity against Ebola virus". Antiviral Research 83 (3): 245–51. September 2009. doi:10.1016/j.antiviral.2009.06.001. PMID 19523489.
↑ "Development of FGI-106 as a broad-spectrum therapeutic with activity against members of the family Bunyaviridae". Virus Adaptation and Treatment: 9. 2010. doi:10.2147/VAAT.S6903.
↑ "Identification of a small-molecule entry inhibitor for filoviruses". Journal of Virology 85 (7): 3106–19. April 2011. doi:10.1128/JVI.01456-10. PMID 21270170.
↑ "Viral hemorrhagic fevers: advancing the level of treatment". BMC Medicine 10: 31. March 2012. doi:10.1186/1741-7015-10-31. PMID 22458265.
↑ "Small molecule inhibitors of ebola virus infection". Drug Discovery Today 20 (2): 277–86. February 2015. doi:10.1016/j.drudis.2014.12.010. PMID 25532798.

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[1] "Development of a broad-spectrum antiviral with activity against Ebola virus". Antiviral Research 83 (3): 245–51. September 2009. doi:10.1016/j.antiviral.2009.06.001. PMID 19523489.

[2] "Development of FGI-106 as a broad-spectrum therapeutic with activity against members of the family Bunyaviridae". Virus Adaptation and Treatment: 9. 2010. doi:10.2147/VAAT.S6903.

[3] "Identification of a small-molecule entry inhibitor for filoviruses". Journal of Virology 85 (7): 3106–19. April 2011. doi:10.1128/JVI.01456-10. PMID 21270170.

[4] "Viral hemorrhagic fevers: advancing the level of treatment". BMC Medicine 10: 31. March 2012. doi:10.1186/1741-7015-10-31. PMID 22458265.

[5] "Small molecule inhibitors of ebola virus infection". Drug Discovery Today 20 (2): 277–86. February 2015. doi:10.1016/j.drudis.2014.12.010. PMID 25532798.

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Legal status	US: Investigational New Drug
Identifiers
IUPAC name N¹,N⁷-bis[3-(dimethylamino)propyl]-3,9-dimethylquinolino[8,7-h]quinoline-1,7-diamine
CAS Number	501081-38-5^Y
PubChem CID	432342
ChemSpider	382357
UNII	BRT994456W
Chemical and physical data
Formula	C₂₈H₃₈N₆
Molar mass	458.654 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN(C)CCCNc(c2ccc14)cc(C)nc2c1ccc3c4nc(C)cc3NCCCN(C)C
InChI InChI=1S/C28H38N6/c1-19-17-25(29-13-7-15-33(3)4)23-11-10-22-21(27(23)31-19)9-12-24-26(18-20(2)32-28(22)24)30-14-8-16-34(5)6/h9-12,17-18H,7-8,13-16H2,1-6H3,(H,29,31)(H,30,32) Key:WJUPENLNVUCETH-UHFFFAOYSA-N

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