Chemistry:Mepiprazole

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Short description: Chemical compound
Mepiprazole
Mepiprazole structure.svg
Clinical data
Trade namesPsigodal
Other namesPAP; EMD-16923; H-4007
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC16H21ClN4
Molar mass304.82 g·mol−1
3D model (JSmol)

Mepiprazole (INN, BAN) (brand name Psigodal) is an anxiolytic drug of the phenylpiperazine group with additional antidepressant properties[1] that is marketed in Spain .[2][3][4][5][6] It acts as a 5-HT2A and α1-adrenergic receptor antagonist[7][8][9] and inhibits the reuptake and induces the release of serotonin, dopamine, and norepinephrine to varying extents,[1][9] and has been described as a serotonin antagonist and reuptake inhibitor (SARI).[10] Controlled clinical trials of mepiprazole in patients with irritable bowel syndrome (IBS) were also carried out and suggested some benefits of the drug in relieving symptoms of IBS in some patients.[11] Similarly to other phenylpiperazines like trazodone, nefazodone, and etoperidone, mepiprazole produces mCPP as an active metabolite.[12]

See also

References

  1. ↑ 1.0 1.1 "Mepiprazole, a new psychotropic drug: effects on uptake and retention of monoamines in rat brain synaptosomes". Psychopharmacology 48 (3): 295–301. August 1976. doi:10.1007/BF00496865. PMID 9660. 
  2. ↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 768–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA768. 
  3. ↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0. https://books.google.com/books?id=5GpcTQD_L2oC&q=mepiprazole&pg=PA648. 
  4. ↑ Pöldinger W (1975). "Clinical trial of 3-methyl-5-(beta-N'-(N-m-chlorophenylpiperazino)ethyl)-pyrazole dihydrochloride (Mepiprazol) in the therapy of psychovegetative disorders". International Pharmacopsychiatry 10 (1): 1–8. doi:10.1159/000468162. PMID 1095510. 
  5. ↑ "[A controlled double-blind crossover study of the efficacy of mepiprazol (EMD 16.923) and of diazepam in the treatment of neurotic disorders]" (in fr). Acta Psychiatrica Belgica 75 (3): 320–33. May 1975. PMID 769484. 
  6. ↑ "[Psychopharmological research with EMD 16-923 in patients with different degrees of anxiety]" (in es). Neurología, Neurocirugía, Psiquiatría 17 (1): 29–33. 1976. PMID 1052713. 
  7. ↑ "Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats". Hypertension 5 (5): 676–81. 1983. doi:10.1161/01.hyp.5.5.676. PMID 6311738. 
  8. ↑ "Central action of mepiprazole". Polish Journal of Pharmacology and Pharmacy 32 (4): 475–84. 1980. PMID 7255266. 
  9. ↑ 9.0 9.1 "The effect of mepiprazole on central monoamine neurons. Evidence for increased 5-hydroxytryptamine and dopamine receptor activity". European Journal of Pharmacology 35 (1): 93–108. January 1976. doi:10.1016/0014-2999(76)90304-6. PMID 943291. 
  10. ↑ "Rediscovering trazodone for the treatment of major depressive disorder". CNS Drugs 26 (12): 1033–1049. December 2012. doi:10.1007/s40263-012-0010-5. PMID 23192413. 
  11. ↑ "Controlled clinical trial of mepiprazole in irritable bowel syndrome". The British Medical Journal 4 (5935): 16–8. October 1974. doi:10.1136/bmj.4.5935.16. PMID 4609545. 
  12. ↑ "1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole". The Journal of Pharmacy and Pharmacology 34 (10): 674–5. October 1982. doi:10.1111/j.2042-7158.1982.tb04701.x. PMID 6128394. 




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