Biology:FGR (gene)
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.[1][2]
Function
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein–Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.[2]
Discovery
The feline version of this gene was discovered by Suraiya Rasheed, Murray Gardner, and co-workers.[3]
Interactions
FGR (gene) has been shown to interact with Wiskott–Aldrich syndrome protein.[4][5][6]
References
- ↑ "Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family". Proc. Natl. Acad. Sci. U.S.A. 82 (19): 6595–9. Oct 1985. doi:10.1073/pnas.82.19.6595. PMID 2995972. Bibcode: 1985PNAS...82.6595T.
- ↑ 2.0 2.1 "Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2268.
- ↑ "Origin and biological properties of a new feline sarcoma virus". Virology 117 (1): 238–44. Feb 1982. doi:10.1016/0042-6822(82)90522-0. PMID 6175084.
- ↑ "Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases". Current Biology 6 (8): 981–8. Aug 1996. doi:10.1016/S0960-9822(02)00642-5. PMID 8805332.
- ↑ "Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains". The Journal of Biological Chemistry 271 (42): 26291–5. Oct 1996. doi:10.1074/jbc.271.42.26291. PMID 8824280. http://espace.library.uq.edu.au/view/UQ:249917/UQ249917_OA.pdf.
- ↑ "Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Molecular and Cellular Biology 15 (10): 5725–31. Oct 1995. doi:10.1128/MCB.15.10.5725. PMID 7565724.
Further reading
- "The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages". Pathobiology 59 (4): 289–92. 1991. doi:10.1159/000163665. PMID 1652975.
- "Myristylation and palmitylation of Src family members: the fats of the matter". Cell 76 (3): 411–3. Feb 1994. doi:10.1016/0092-8674(94)90104-X. PMID 8313462.
- "Integrin signal transduction in myeloid leukocytes". Journal of Leukocyte Biology 65 (3): 313–20. Mar 1999. doi:10.1002/jlb.65.3.313. PMID 10080533.
- "The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization". Annual Review of Immunology 17 (1): 905–29. 1999. doi:10.1146/annurev.immunol.17.1.905. PMID 10358777.
- "Kinases of the Src family: structure and functions". Biochemistry. Biokhimiia 65 (1): 49–58. Jan 2000. PMID 10702640.
- "A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1". Human Molecular Genetics 1 (1): 65. Apr 1992. doi:10.1093/hmg/1.1.65-a. PMID 1339476.
- "Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter". Oncogene 7 (5): 877–84. May 1992. PMID 1373875.
- "Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites". Oncogene 5 (2): 201–6. Feb 1990. PMID 1690869.
- "Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells". European Journal of Immunology 21 (3): 843–6. Mar 1991. doi:10.1002/eji.1830210348. PMID 1826268.
- "A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes". Molecular and Cellular Biology 11 (3): 1500–7. Mar 1991. doi:10.1128/MCB.11.3.1500. PMID 1847500.
- "Regulation of c-fgr proto-oncogene expression in Epstein-Barr virus infected B-cell lines". International Journal of Cancer 45 (2): 342–6. Feb 1990. doi:10.1002/ijc.2910450222. PMID 2154410.
- "Isolation of duplicated human c-src genes located on chromosomes 1 and 20". Molecular and Cellular Biology 5 (4): 831–8. Apr 1985. doi:10.1128/MCB.5.4.831. PMID 2581127.
- "Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines". British Journal of Cancer 58 (6): 704–9. Dec 1988. doi:10.1038/bjc.1988.294. PMID 2852026.
- "Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family". Proceedings of the National Academy of Sciences of the United States of America 82 (19): 6595–9. Oct 1985. doi:10.1073/pnas.82.19.6595. PMID 2995972. Bibcode: 1985PNAS...82.6595T.
- "fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection". Nature 319 (6050): 238–40. 1986. doi:10.1038/319238a0. PMID 3003578. Bibcode: 1986Natur.319..238C. https://zenodo.org/record/1233045.
- "Structure, expression, and chromosomal location of the human c-fgr gene". Molecular and Cellular Biology 6 (2): 511–7. Feb 1986. doi:10.1128/MCB.6.2.511. PMID 3023853.
- "Primary structure of the human fgr proto-oncogene product p55c-fgr". Molecular and Cellular Biology 8 (1): 259–66. Jan 1988. doi:10.1128/MCB.8.1.259. PMID 3275868.
- "Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9". Oncogene 1 (3): 301–4. 1988. PMID 3330776.
- "Human c-f gr gene does not contain coding sequence for actin-like protein". Japanese Journal of Cancer Research 76 (3): 155–9. Mar 1985. PMID 3922831.
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