Biology:DNA polymerase delta
From HandWiki
Short description: Enzyme complex
| DNA-directed DNA polymerase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.7.7.7 | ||||||||
| CAS number | 9012-90-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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DNA polymerase delta (DNA Pol δ) is an enzyme complex found in eukaryotes that is involved in DNA replication and repair. The DNA polymerase delta complex consists of 4 subunits: POLD1, POLD2, POLD3, and POLD4.[1] DNA Pol δ is an enzyme used for both leading and lagging strand synthesis.[2][3] It exhibits increased processivity when interacting with the proliferating cell nuclear antigen (PCNA). As well, the multisubunit protein replication factor C, through its role as the clamp loader for PCNA (which involves catalysing the loading of PCNA on to DNA) is important for DNA Pol δ function.[citation needed]
References
- ↑ "The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins". Biochemical and Biophysical Research Communications 349 (1): 360–6. October 2006. doi:10.1016/j.bbrc.2006.08.049. PMID 16934752.
- ↑ "A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands". Molecular Cell 59 (2): 163–175. July 2015. doi:10.1016/j.molcel.2015.05.038. PMID 26145172.
- ↑ "DNA Polymerases Divide the Labor of Genome Replication". Trends in Cell Biology 26 (9): 640–654. September 2016. doi:10.1016/j.tcb.2016.04.012. PMID 27262731.
External links
- DNA+polymerase+delta at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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