Biology:1-Pyrroline-5-carboxylate dehydrogenase
| 1-pyrroline-5-carboxylate dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.2.1.88 | ||||||||
| CAS number | 9054-82-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) is an enzyme that catalyzes the chemical reaction
- (S)-1-pyrroline-5-carboxylate + NAD+ + 2 H2O [math]\displaystyle{ \rightleftharpoons }[/math] L-glutamate + NADH + H+
The three substrates of this enzyme are (S)-1-pyrroline-5-carboxylate, NAD+, and H2O, whereas its three products are glutamate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase. Other names in common use include delta-1-pyrroline-5-carboxylate dehydrogenase, 1-pyrroline dehydrogenase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylic acid dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, and 1-pyrroline-5-carboxylate:NAD+ oxidoreductase. This enzyme participates in glutamate metabolism and arginine and proline metabolism.
Structural studies
As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 2BHP, 2BHQ, 2BJA, 2BJK, 2EHQ, 2EHU, 2EII, 2EIT, 2EIW, 2EJ6, 2EJD, 2EJL, 2IY6, and 2J40.
Human gene
In human, the protein is encoded by ALDH4A1 gene.
References
- "Hydroxyproline metabolism. IV. Enzymatic synthesis of gamma-hydroxyglutamate from Delta 1-pyrroline-3-hydroxy-5-carboxylate". The Journal of Biological Chemistry 235 (12): 3504–12. December 1960. doi:10.1016/S0021-9258(18)64498-9. PMID 13681370.
- "The interconversion of glutamic acid proline. III Delta1-Pyrroline-5-carboxylic acid dehydrogenase". J. Biol. Chem. 235: 3218–3223. 1960. doi:10.1016/S0021-9258(20)81340-4.
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