Biology:Aminocarboxymuconate-semialdehyde decarboxylase
| aminocarboxymuconate-semialdehyde decarboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 aminocarboxymuconate-semialdehyde decarboxylase dimer, Human | |||||||||
| Identifiers | |||||||||
| EC number | 4.1.1.45 | ||||||||
| CAS number | 37289-47-7 | ||||||||
| Alt. names | ACMSD | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme aminocarboxymuconate-semialdehyde decarboxylase (EC 4.1.1.45) catalyzes the chemical reaction:[1]
- REDIRECT Template:Chemical reaction
The product spontaneously ring-closes to picolinic acid, with loss of water.[2][3]
- REDIRECT Template:Chemical reaction
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. This enzyme is part of the kynurenine pathway in tryptophan metabolism, leading to picolinic acid or quinolinic acid.[3] It has been identified as a marker in nonverbal autism.[4]
Nomenclature
The systematic name of this enzyme class is 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming). Other names in common use include picolinic acid carboxylase, picolinic acid decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehyde, beta-decarboxylase, 2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase, and 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase.[1]
References
- ↑ 1.0 1.1 Enzyme 4.1.1.45 at KEGG Pathway Database.
- ↑ "Studies on the Metabolism of the Benzene Ring of Tryptophan in Mammalian Tissues". Journal of Biological Chemistry 240 (2): 740–749. 1965. doi:10.1016/S0021-9258(17)45238-0.
- ↑ 3.0 3.1 "The kynurenine pathway: a finger in every pie". Molecular Psychiatry 25 (1): 131–147. January 2020. doi:10.1038/s41380-019-0414-4. PMID 30980044.
- ↑ "Structural variants identified using non-Mendelian inheritance patterns advance the mechanistic understanding of autism spectrum disorder". HGG Advances 4 (1). January 2023. doi:10.1016/j.xhgg.2022.100150. PMID 36340933.
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