Biology:TYRO3

Generic protein structure example

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.

Interactions

TYRO3 has been shown to interact with:

• GAS6, and
• PIK3R1

Further reading

• "rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain". J. Biol. Chem. 269 (14): 10720–8. 1994. doi:10.1016/S0021-9258(17)34118-2. PMID 7511603. 
• "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase". Biochem. Biophys. Res. Commun. 209 (2): 656–63. 1995. doi:10.1006/bbrc.1995.1549. PMID 7537495. 
• "Isolation and characterization of the human DTK receptor tyrosine kinase". Growth Factors 11 (2): 137–44. 1995. doi:10.3109/08977199409001055. PMID 7857658. 
• "Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain". Oncogene 9 (3): 699–705. 1994. PMID 8108112. 
• "Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis". Oncogene 9 (3): 975–9. 1994. PMID 8108143. 
• "The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25". Gene 134 (2): 289–93. 1994. doi:10.1016/0378-1119(93)90109-G. PMID 8262388. 
• "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. 271 (16): 9785–9. 1996. doi:10.1074/jbc.271.16.9785. PMID 8621659. 
• "The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis". Exp. Hematol. 24 (2): 318–23. 1996. PMID 8641360. 
• "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. 271 (47): 30022–7. 1997. doi:10.1074/jbc.271.47.30022. PMID 8939948. 
• "A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress". Biol. Cell 88 (1–2): 45–54. 1997. doi:10.1016/S0248-4900(97)86830-X. PMID 9175267. 
• "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". Blood 95 (2): 633–8. 2000. doi:10.1182/blood.V95.2.633. PMID 10627473. 
• "Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts". Transpl. Int. 16 (9): 681–8. 2004. doi:10.1007/s00147-003-0593-3. PMID 12768229. 
• "Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family". J. Biol. Chem. 279 (8): 6952–8. 2004. doi:10.1074/jbc.M311750200. PMID 14623883. 
• "Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses". J. Thromb. Haemost. 3 (4): 733–41. 2005. doi:10.1111/j.1538-7836.2005.01186.x. PMID 15733062. 
• "The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases". Int. J. Biochem. Cell Biol. 37 (11): 2344–56. 2005. doi:10.1016/j.biocel.2005.05.006. PMID 15964779. 
• "Tyro3 Family-Mediated Cell Entry of Ebola and Marburg Viruses". J. Virol. 80 (20): 10109–16. 2006. doi:10.1128/JVI.01157-06. PMID 17005688.